在自身免疫性B/W小鼠中产生的单克隆抗DNA抗体的独特型在正常小鼠中表达。
Idiotypes of monoclonal anti-DNA antibodies produced in autoimmune B/W mice are expressed in normal mice.
作者信息
Jacob L, Tron F, Lety M A, Bach J F
出版信息
Clin Exp Immunol. 1986 Feb;63(2):402-7.
Abstract
An anti-idiotypic antiserum was prepared in a rabbit immunized against a pool of six monoclonal anti-DNA antibodies generated in B/W mice. This antiserum detected idiotypic determinants in four of the six monoclonal anti-DNA antibodies but also in the serum of several non autoimmune strains (BALB/c, NZB X BALB/c) F1 hybrids & CBA/LH). The antiserum also reacted, but only to a weak degree, with B/W mouse sera. These results indicate that some idiotypes of anti-DNA antibodies produced by autoimmune B/W mice are present in normal mouse sera.
摘要
用针对在B/W小鼠中产生的六种单克隆抗DNA抗体混合液免疫的兔子制备了一种抗独特型抗血清。该抗血清在六种单克隆抗DNA抗体中的四种中检测到独特型决定簇，而且在几种非自身免疫品系（BALB/c、NZB×BALB/c）F1杂种小鼠和CBA/LH小鼠的血清中也检测到了。该抗血清与B/W小鼠血清也有反应，但程度较弱。这些结果表明，自身免疫性B/W小鼠产生的一些抗DNA抗体独特型存在于正常小鼠血清中。
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