van Maarsseven A C, Mullink H, Alons C L, Stam J
Hum Pathol. 1986 May;17(5):493-500. doi: 10.1016/s0046-8177(86)80040-5.
The numbers and the distribution of T-lymphocyte subpopulations in lymph node granulomas from 11 patients with sarcoidosis were studied in cryostat sections by an immunoperoxidase technique. Greater numbers of helper T lymphocytes (Leu-3+) were found at the periphery than in the central portion of the same granuloma. Most of the suppressor T lymphocytes (OKT8+) were present at the periphery of the granulomas. In addition, the Leu-3a/OKT8 ratio varied from 0.7 to 1.8 in the outer compartment, while in the central portion of the granuloma much higher values (3 to 20) were found. These different distribution patterns of T-lymphocyte subsets provide evidence for two different compartments with different immune reactions in sarcoid granulomas.
采用免疫过氧化物酶技术，在冷冻切片上对11例结节病患者淋巴结肉芽肿中的T淋巴细胞亚群数量及分布进行了研究。在同一肉芽肿的周边发现的辅助性T淋巴细胞（Leu-3+）数量多于中央部分。大多数抑制性T淋巴细胞（OKT8+）存在于肉芽肿的周边。此外，在外层区域Leu-3a/OKT8比值在0.7至1.8之间变化，而在肉芽肿的中央部分则发现更高的值（3至20）。T淋巴细胞亚群的这些不同分布模式为结节病肉芽肿中具有不同免疫反应的两个不同区域提供了证据。
