McChesney M B, Fujinami R S, Lampert P W, Oldstone M B
J Exp Med. 1986 May 1;163(5):1331-6.
Measles virus infection is associated with suppression of immune functions both in vivo and in vitro. The virus infects T lymphocytes, B lymphocytes, and monocytes, but does not produce cytolysis. One consequence of infection in vitro is the failure of T and B lymphocyte mixtures to cooperate in secreting Ig in a PWM-driven system. Here we report that this defect in Ig secretion resides in the infected B lymphocyte, but not in the T lymphocyte or monocyte. Further, NK cells are not involved, since neither their depletion nor reconstitution abrogates suppression of B cell function. Proliferation of B cells in the early culture period is suppressed, suggesting that measles virus suppresses B cell development at the activation or proliferation stages, but does not affect terminal differentiation into Ig secreting cells.
麻疹病毒感染在体内和体外均与免疫功能抑制相关。该病毒感染T淋巴细胞、B淋巴细胞和单核细胞，但不产生细胞溶解。体外感染的一个后果是在PWM驱动系统中T和B淋巴细胞混合物无法协同分泌免疫球蛋白（Ig）。在此我们报告，Ig分泌的这种缺陷存在于受感染的B淋巴细胞中，而非T淋巴细胞或单核细胞中。此外，自然杀伤（NK）细胞不参与其中，因为它们的耗竭或重建均不能消除对B细胞功能的抑制。早期培养阶段B细胞的增殖受到抑制，这表明麻疹病毒在激活或增殖阶段抑制B细胞发育，但不影响其向Ig分泌细胞的终末分化。
