McKenna R M, Ofosu-Appiah W, Warrington R J, Wilkins J A
J Rheumatol. 1986 Feb;13(1):28-32.
The interleukin 2 (IL-2) production and responsiveness of peripheral blood lymphocytes from patients with rheumatoid arthritis (RA) with active or inactive disease was compared with that of normal control donors. IL-2 production was assessed using a cellular interleukin assay in which an IL-2 dependent cell line was cocultured with varying numbers of irradiated IL-2 producing lymphocytes from the different donor sources. Cells from patients with active disease showed a significantly different pattern of IL-2 production from that of control or inactive RA patients in that a lower number of cells supported growth of the IL-2 dependent cell line. In one patient this shift in pattern was shown to correlate with change in disease activity. Lymphocyte responsiveness to IL-2 as determined by limiting dilution analysis did not differ significantly between the different groups. The results are consistent with a hyperproduction of IL-2 in RA during active disease.
将类风湿性关节炎（RA）活动期或非活动期患者外周血淋巴细胞的白细胞介素2（IL-2）产生情况及反应性与正常对照供体进行了比较。使用细胞白细胞介素检测法评估IL-2的产生，即将IL-2依赖细胞系与来自不同供体来源的不同数量经辐照的产生IL-2的淋巴细胞共培养。活动期疾病患者的细胞与对照或非活动期RA患者相比，IL-2产生模式有显著差异，即支持IL-2依赖细胞系生长的细胞数量较少。在一名患者中，这种模式转变与疾病活动度变化相关。通过有限稀释分析确定的淋巴细胞对IL-2的反应性在不同组之间无显著差异。结果与活动期疾病时RA中IL-2的过度产生一致。
