McKenna R M, Wilkins J A, Warrington R J
Rheumatic Disease Unit Research Laboratory, Health Sciences Centre, Winnipeg, MB, Canada.
J Rheumatol. 1988 Nov;15(11):1639-42.
The production of interferon (IFN) by peripheral blood lymphocytes from patients with rheumatoid arthritis (RA) and of IFN and interleukin 2 (IL-2) in systemic lupus erythematosus (SLE) was compared with that of healthy controls. Patients with SLE showed a significant reduction in IL-2 production compared to controls if the PBL were irradiated before mitogen stimulation. No patient with RA or SLE studied had impaired IFN production regardless of disease activity and the IFN produced was always IFN-gamma in type. We conclude that there is an abnormality in IL-2 production in SLE but there is no abnormality in IFN-gamma production in either RA or SLE.
将类风湿性关节炎（RA）患者外周血淋巴细胞产生干扰素（IFN）的情况，以及系统性红斑狼疮（SLE）患者产生干扰素和白细胞介素2（IL-2）的情况，与健康对照者进行了比较。如果在有丝分裂原刺激前对外周血淋巴细胞（PBL）进行照射，SLE患者与对照者相比，IL-2产生显著减少。无论疾病活动情况如何，所研究的RA或SLE患者均未出现IFN产生受损的情况，且所产生的IFN类型始终为γ干扰素。我们得出结论，SLE患者存在IL-2产生异常，但RA或SLE患者的γ干扰素产生均无异常。
