Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Immunology, 280 South Chongqing Road, Shanghai 200025, China.
Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 Xianxia Road, Shanghai 200336, China.
Mediators Inflamm. 2021 Nov 26;2021:9087816. doi: 10.1155/2021/9087816. eCollection 2021.
Prostaglandin E2 (PGE) is a lipid mediator derived from the fatty acid arachidonic acid. As an essential inflammatory factor, PGE has a critical impact on immune regulation through the prostanoid E (EP) receptor pathway. T cells, including CD4 and CD8 T cell subsets, play crucial roles in the adaptive immune response. Previous studies have shown that PGE is involved in regulating CD4 T cell differentiation and inflammatory cytokine production via the EP receptor pathway, thereby affecting the development of diseases mediated by CD4 T cells. In this review, we summarize the signaling pathway of PGE and describe the relationship between PGE and T cell differentiation. Hence, this review may provide important evidence for immune therapies and may even promote the development of biomedicines.
前列腺素 E2（PGE）是一种源自脂肪酸花生四烯酸的脂类介质。作为一种重要的炎症因子，PGE 通过前列腺素 E（EP）受体途径对免疫调节具有关键影响。T 细胞，包括 CD4 和 CD8 T 细胞亚群，在适应性免疫反应中发挥着至关重要的作用。先前的研究表明，PGE 通过 EP 受体途径参与调节 CD4 T 细胞分化和炎症细胞因子的产生，从而影响由 CD4 T 细胞介导的疾病的发展。在这篇综述中，我们总结了 PGE 的信号通路，并描述了 PGE 与 T 细胞分化之间的关系。因此，这篇综述可能为免疫治疗提供重要依据，甚至可能促进生物医学的发展。
