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贡柑（Citrus Reticulata Blanco Var. Gonggan）果皮提取物对乙醇/盐酸诱导的小鼠胃损伤的预防作用——一种抗氧化机制

Preventive Effect of Gonggan (Citrus Reticulata Blanco Var. Gonggan) Peel Extract on Ethanol/HCl-Induced Gastric Injury in Mice an Anti-oxidative Mechanism.

作者信息

Wu Ya, Jiang Hua, Chen Guangfang, Chen Xingxing, Hu Chengming, Su Xiaofei, Tan Fang, Zhao Xin

机构信息

Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing, China.

Chongqing Engineering Research Center of Functional Food, Chongqing University of Education, Chongqing, China.

出版信息

Front Pharmacol. 2021 Nov 17;12:715306. doi: 10.3389/fphar.2021.715306. eCollection 2021.

DOI:10.3389/fphar.2021.715306
PMID:34867323
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8635765/
Abstract

Gonggan (Citrus reticulata Blanco var. gonggan) is one of the most popular citruses. In this study, the effect of Gonggan peel extract (GPE) on gastric injury was investigated. The components in GPE were analysed by HPLC and the gastric injury model in mice was established by ethanol/hydrochloric acid. After treatment by GPE, the pathological changes of gastric tissue were observed by optical microscope. The levels of oxidative stress and inflammation were measure by kit. And the mRNA expression of related gene was determined by qPCR assay. HPLC result showed GPE mainly contained the flavonoids narirutin, hesperidin, nobiletin, tangeretin and 5-demethylnobiletin. Morphological and pathological analysis of gastric tissue revealed that GPE could relieve gastric injury. Also, GPE increased the levels of SOD, GSH-Px, and CAT and decreased the level of MDA. Moreover, GPE decreased the levels of the inflammatory cytokines TNF-α, IFN-γ, IL-1β, and IL-6 to suppress inflammation. In addition, the q-PCR results showed that GPE upregulated the mRNA expression of SOD1, SOD2, γ-GCS, GSH-Px, CAT, and IκBα and downregulated the mRNA expression of NF-κB. In conclusion, GPE alleviated gastric injury caused by ethanol/hydrochloric acid by inhibiting oxidative stress and the inflammatory response. The mechanism by which GPE protects gastric tissues may involve the antioxidative pathway. Therefore, GPE has great potential to be developed as a product to prevent gastric injury.

摘要

贡柑（Citrus reticulata Blanco var. gonggan）是最受欢迎的柑橘类水果之一。在本研究中，研究了贡柑果皮提取物（GPE）对胃损伤的影响。通过高效液相色谱法（HPLC）分析GPE中的成分，并通过乙醇/盐酸建立小鼠胃损伤模型。用GPE处理后，通过光学显微镜观察胃组织的病理变化。用试剂盒检测氧化应激和炎症水平。并通过qPCR测定相关基因的mRNA表达。HPLC结果显示，GPE主要含有黄酮类化合物橙皮苷、柚皮苷、川陈皮素、橘皮素和5-去甲基川陈皮素。胃组织的形态学和病理学分析表明，GPE可以减轻胃损伤。此外，GPE提高了超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）和过氧化氢酶（CAT）的水平，并降低了丙二醛（MDA）的水平。此外，GPE降低了炎性细胞因子肿瘤坏死因子-α（TNF-α）、干扰素-γ（IFN-γ）、白细胞介素-1β（IL-1β）和白细胞介素-6（IL-6）的水平以抑制炎症。此外，q-PCR结果显示，GPE上调了SOD1、SOD2、γ-谷氨酰半胱氨酸合成酶（γ-GCS）、GSH-Px、CAT和核因子κB抑制蛋白α（IκBα）的mRNA表达，并下调了核因子κB（NF-κB）的mRNA表达。总之，GPE通过抑制氧化应激和炎症反应减轻了乙醇/盐酸引起的胃损伤。GPE保护胃组织的机制可能涉及抗氧化途径。因此，GPE具有开发成预防胃损伤产品的巨大潜力。

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