系统性红斑狼疮肾炎患者的血小板相关DNA及抗DNA抗体
Platelet-associated DNA and anti-DNA antibody in systemic lupus erythematosus with nephritis.
作者信息
Frampton G, Perl S, Bennett A, Cameron J S
出版信息
Clin Exp Immunol. 1986 Mar;63(3):621-8.
Abstract
We report DNA and specific anti-dsDNA antibody (dsDNAb) in excess of controls, associated with platelets from 35 patients with systemic lupus erythematosus (SLE). Deoxyribonuclease (DNase) treatment of intact platelets resulted not only in a drop in platelet-associated DNA, but also a dramatic fall in platelet-associated dsDNAb. This suggests that at least some DNA and virtually all the dsDNAb is bound to the platelet surface, probably in the form of an immune complex. The quantity of platelet-associated DNA did not correlate with amounts of platelet-associated anti-dsDNA antibody (PAdsDNAb); perhaps because platelets also have receptors for DNA itself. Total platelet-associated IgG was elevated in only six patients with normal PAdsDNab.
摘要
我们报告了35例系统性红斑狼疮（SLE）患者的血小板中，DNA及特异性抗双链DNA抗体（dsDNAb）含量超过对照组。用脱氧核糖核酸酶（DNase）处理完整血小板，不仅会使血小板相关DNA含量下降，还会使血小板相关dsDNAb显著减少。这表明至少部分DNA以及几乎所有的dsDNAb都以免疫复合物的形式结合在血小板表面。血小板相关DNA的量与血小板相关抗dsDNA抗体（PAdsDNAb）的量不相关；这可能是因为血小板本身也有DNA受体。仅6例PAdsDNab正常的患者血小板相关总IgG升高。
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