Rao Benchen, Ren Tong, Wang Xuemei, Wang Haiyu, Zou Yawen, Sun Ying, Liu Shanshuo, Ren Zhigang, Yu Zujiang
Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Gene Hospital of Henan Province, Precision Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Front Physiol. 2021 Nov 12;12:715536. doi: 10.3389/fphys.2021.715536. eCollection 2021.
Cholangiocarcinoma (CCA) is the most common malignant tumor of the biliary system with a very poor prognosis. The human microbiome, which is the sum of the genetic information of human microorganisms, plays an important role in regulating the digestion, absorption, immune response, and metabolism of the host. Increasing evidence indicates a close relationship between CCA and the human microbiome. Specific alterations occur in the human microbiome of patients with CCA. Therefore, in this review, we aimed to summarize the recent evidence on dysbiosis in the human microbiome of CCA. Then, we generalized the effect of on CCA. Additionally, the potential mechanism of human microbial dysbiosis promoted the progress of CCA, and its precancerous disease was also explored. Furthermore, the possibility of the human microbiome as a diagnostic and therapeutic target of CCA was discussed.
胆管癌（CCA）是胆道系统最常见的恶性肿瘤，预后极差。人类微生物组是人类微生物遗传信息的总和，在调节宿主的消化、吸收、免疫反应和代谢方面发挥着重要作用。越来越多的证据表明CCA与人类微生物组之间存在密切关系。CCA患者的人类微生物组会发生特定改变。因此，在本综述中，我们旨在总结近期关于CCA患者人类微生物组失调的证据。然后，我们归纳了其对CCA的影响。此外，还探讨了人类微生物失调促进CCA进展及其癌前疾病的潜在机制。此外，还讨论了人类微生物组作为CCA诊断和治疗靶点的可能性。
