Weiss L M, Wood G S, Dorfman R F
Am J Surg Pathol. 1985 Apr;9(4):273-80.
The histologic, ultrastructural, and immunologic characteristics of two signet-ring cell lymphomas of T-cell derivation are presented. Histologically, both lymphomas were diffuse large cell lymphomas with many neoplastic cells containing cytoplasmic vacuoles imparting a signet-ring configuration. Ultrastructural examination revealed the vacuoles to consist of electron-lucent spaces containing variable numbers of microspherules. Immunohistochemical studies showed that both lymphomas expressed T-cell phenotypes with no reactivity with antibodies to B-cell antigens. In contrast to previous reports which have shown signet-ring cell lymphomas to be invariably B-cell in derivation and usually follicular center cell type, this study demonstrates that these lymphomas may also be of T-cell origin.
本文介绍了两例T细胞来源的印戒细胞淋巴瘤的组织学、超微结构和免疫学特征。组织学上，这两种淋巴瘤均为弥漫性大细胞淋巴瘤，许多肿瘤细胞含有细胞质空泡，呈现印戒样形态。超微结构检查显示，这些空泡由含有数量不等微球的电子透亮区组成。免疫组织化学研究表明，这两种淋巴瘤均表达T细胞表型，与B细胞抗原抗体无反应性。与以往报道显示印戒细胞淋巴瘤均为B细胞来源且通常为滤泡中心细胞型不同，本研究表明这些淋巴瘤也可能起源于T细胞。
