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Effects of Red and Fermented Ginseng and Ginsenosides on Allergic Disorders.红参及发酵红参和人参皂苷对过敏性疾病的影响。
Biomolecules. 2020 Apr 20;10(4):634. doi: 10.3390/biom10040634.
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Ginsenoside Rb1 exerts neuroprotective effects through regulation of abundance and GABA receptor expression.人参皂苷Rb1通过调节丰度和GABA受体表达发挥神经保护作用。
J Ginseng Res. 2020 Jan;44(1):86-95. doi: 10.1016/j.jgr.2018.09.002. Epub 2018 Sep 19.
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Prostaglandin E2 signal inhibits T regulatory cell differentiation during allergic rhinitis inflammation through EP4 receptor.前列腺素E2信号通过EP4受体在变应性鼻炎炎症过程中抑制调节性T细胞分化。
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Dendritic Cells Expressing MyD88 Molecule Are Necessary and Sufficient for CpG-Mediated Inhibition of IgE Production In Vivo.树突状细胞表达 MyD88 分子对于 CpG 介导的体内 IgE 产生抑制是必要且充分的。
Cells. 2019 Sep 28;8(10):1165. doi: 10.3390/cells8101165.
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An Updated Review on Pharmaceutical Properties of Gamma-Aminobutyric Acid.γ-氨基丁酸的药物特性更新研究综述。
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Ginsenoside Rb1 regulates prefrontal cortical GABAergic transmission in MPTP-treated mice.人参皂苷Rb1调节MPTP处理小鼠的前额叶皮质GABA能传递。
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The Cytokines of Asthma.哮喘的细胞因子。
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Antibiotics and autoimmune and allergy diseases: Causative factor or treatment?抗生素与自身免疫和过敏疾病：病因还是治疗手段？
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GABAergic signaling linked to autophagy enhances host protection against intracellular bacterial infections.GABAergic 信号与自噬相关，增强宿主对内源性细菌感染的保护作用。
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Anti-IL-5 treatments in patients with severe asthma by blood eosinophil thresholds: Indirect treatment comparison.血嗜酸性粒细胞阈值指导下的重度哮喘患者的抗 IL-5 治疗：间接治疗比较。
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韩国红参提取物与γ-氨基丁酸混合物通过Th1/Th2细胞平衡对小鼠IgE产生的协同作用。

Synergistic effect of Korean red ginseng extract and GABA mixture on the IgE production in mice via Th1/Th2 cell balance.

作者信息

Lim Jung Sik, Kim Chae Rim, Shin Kwang Soon, Lee Sue Jung, Yoon Taek Joon, Park Hee Jung

机构信息

Department of Food and Nutrition, Yuhan University, 590, Kyungin-ro, Buchoen, 14780 Republic of Korea.

Department of Food Science and Biotechnology, Kyonggi University, 154-42, Gwnggyosan-ro, Yeongtong-gu, Suwon, 16227 Republic of Korea.

出版信息

Food Sci Biotechnol. 2021 Oct 28;30(12):1571-1580. doi: 10.1007/s10068-021-00985-x. eCollection 2021 Nov.

DOI:10.1007/s10068-021-00985-x
PMID:34868705
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8595434/
Abstract

It has been recently reported that the immune system has been linked to the nervous system. This study was conducted to investigate the effect of administration of two components, gamma-aminobutyric acid (GABA) and Panax ginseng Meyer (GIN), on the production of IgE and Th1-Th2 dominant cytokines. Antibody and inflammatory mediator levels in serum, and the cytokines secreted to spleen cells of ovalbumin (OVA) immunized mice were analyzed. The group of GABA and GIN mixture significantly reduced IgE level and dramatically increased OVA-IgG2a antibody production. In addition, rising effect on IFN-gamma and GM-CSF levels related to Th1 cytokine was observed only in the group of GABA + GIN. The mixture alleviated allergic symptoms by reducing the level of histamine and prostaglandin. These studies suggest that GIN + GABA administration in the allergen-induced mouse model may regulate the Th1-Th2 balance by strongly acting on the immune response associated with Th1.

摘要

最近有报道称，免疫系统与神经系统有关联。本研究旨在调查两种成分，即γ-氨基丁酸（GABA）和人参（GIN）的给药对IgE以及Th1-Th2优势细胞因子产生的影响。分析了血清中的抗体和炎症介质水平，以及卵清蛋白（OVA）免疫小鼠脾细胞分泌的细胞因子。GABA和GIN混合物组显著降低了IgE水平，并显著增加了OVA-IgG2a抗体的产生。此外，仅在GABA + GIN组观察到对与Th1细胞因子相关的IFN-γ和GM-CSF水平有升高作用。该混合物通过降低组胺和前列腺素水平减轻了过敏症状。这些研究表明，在变应原诱导的小鼠模型中给予GIN + GABA可能通过强烈作用于与Th1相关的免疫反应来调节Th1-Th2平衡。