Heli Zhou, Hongyu Chen, Dapeng Bao, Yee Shin Tan, Yejun Zhong, Xi Zhang, Yingying Wu
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China.
National Engineering Research Center of Edible Fungi, Key Laboratory of Applied Mycological Resources and Utilization of Ministry of Agriculture, Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai, China.
Front Nutr. 2022 Dec 22;9:1076223. doi: 10.3389/fnut.2022.1076223. eCollection 2022.
γ-aminobutyric acid (GABA) is a non-protein amino acid which naturally and widely occurs in animals, plants, and microorganisms. As the chief inhibitory neurotransmitter in the central nervous system of mammals, it has become a popular dietary supplement and has promising application in food industry. The current article reviews the most recent literature regarding the physiological functions, preparation methods, enrichment methods, metabolic pathways, and applications of GABA. This review sheds light on developing GABA-enriched plant varieties and food products, and provides insights for efficient production of GABA through synthetic biology approaches.
γ-氨基丁酸（GABA）是一种非蛋白质氨基酸，天然广泛存在于动物、植物和微生物中。作为哺乳动物中枢神经系统中的主要抑制性神经递质，它已成为一种受欢迎的膳食补充剂，在食品工业中具有广阔的应用前景。本文综述了关于GABA的生理功能、制备方法、富集方法、代谢途径及应用的最新文献。该综述为开发富含GABA的植物品种和食品提供了思路，并为通过合成生物学方法高效生产GABA提供了见解。
