Mao Chenyu, Ding Yongfeng, Xu Nong
Department of Medical Oncology Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Front Oncol. 2021 Nov 16;11:688489. doi: 10.3389/fonc.2021.688489. eCollection 2021.
Prostate cancer (PC) is one of the most common malignancies among men and is the second leading cause of cancer death. PC immunotherapy has taken relatively successful steps in recent years, and these treatments are still being developed and tested. Evidence suggests that immunotherapy using cytokines as essential mediators in the immune system may help treat cancer. It has been shown that cytokines play an important role in anti-tumor defense. On the other hand, other cytokines can also favor the tumor and suppress anti-tumor responses. Moreover, the dose of cytokine in cancer cytokine-based immunotherapy, as well as the side effects of high doses, can also affect the outcomes of treatment. Cytokines can also be determinative in the outcome of other immunotherapy methods used in PC. In this review, the role of cytokines in the pathogenesis of cancer and their impacts on the main types of immunotherapies in the treatment of PC are discussed.
前列腺癌（PC）是男性中最常见的恶性肿瘤之一，也是癌症死亡的第二大主要原因。近年来，PC免疫疗法已取得了相对成功的进展，并且这些治疗方法仍在不断研发和测试中。有证据表明，使用细胞因子作为免疫系统中的关键介质进行免疫治疗可能有助于治疗癌症。研究表明，细胞因子在抗肿瘤防御中发挥着重要作用。另一方面，其他细胞因子也可能促进肿瘤生长并抑制抗肿瘤反应。此外，基于细胞因子的癌症免疫疗法中细胞因子的剂量以及高剂量的副作用，也会影响治疗效果。细胞因子在PC中使用的其他免疫疗法的结果中也可能起决定性作用。在本综述中，将讨论细胞因子在癌症发病机制中的作用及其对PC治疗中主要免疫疗法类型的影响。
