Shen Xue, Liu Xiyang, Li Tingting, Chen Yin, Chen Yang, Wang Pan, Zheng Lin, Yang Hong, Wu Chunhui, Deng Shengqi, Liu Yiyao
Engineering Research Center for Pharmaceuticals and Equipments of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu, China.
School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Front Chem. 2021 Nov 18;9:746646. doi: 10.3389/fchem.2021.746646. eCollection 2021.
Recently, drug delivery vehicles based on nanotechnology have significantly attracted the attention of researchers in the field of nanomedicine since they can achieve ideal drug release and biodistribution. Among the various organic or inorganic materials that used to prepare drug delivery vehicles for effective cancer treatment, serum albumin-based nanovehicles have been widely developed and investigated due to their prominent superiorities, including good biocompatibility, high stability, nontoxicity, non-immunogenicity, easy preparation, and functionalization, allowing them to be promising candidates for cancer diagnosis and therapy. This article reviews the recent advances on the applications of serum albumin-based nanovehicles in cancer diagnosis and therapy. We first introduce the essential information of bovine serum albumin (BSA) and human serum albumin (HSA), and discuss their drug loading strategies. We then discuss the different types of serum albumin-based nanovehicles including albumin nanoparticles, surface-functionalized albumin nanoparticles, and albumin nanocomplexes. Moreover, after briefly discussing the application of serum albumin-based nanovehicles used as the nanoprobes in cancer diagnosis, we also describe the serum albumin-based nanovehicle-assisted cancer theranostics, involving gas therapy, chemodynamic therapy (CDT), phototherapy (PTT/PDT), sonodynamic therapy (SDT), and other therapies as well as cancer imaging. Numerous studies cited in our review show that serum albumin-based nanovehicles possess a great potential in cancer diagnostic and therapeutic applications.
近年来，基于纳米技术的药物递送载体在纳米医学领域引起了研究人员的极大关注，因为它们能够实现理想的药物释放和生物分布。在用于制备有效癌症治疗药物递送载体的各种有机或无机材料中，基于血清白蛋白的纳米载体因其突出的优势，包括良好的生物相容性、高稳定性、无毒、无免疫原性、易于制备和功能化，而得到了广泛的开发和研究，使其成为癌症诊断和治疗的有前途的候选者。本文综述了基于血清白蛋白的纳米载体在癌症诊断和治疗中的应用进展。我们首先介绍牛血清白蛋白（BSA）和人血清白蛋白（HSA）的基本信息，并讨论它们的载药策略。然后我们讨论了不同类型的基于血清白蛋白的纳米载体，包括白蛋白纳米颗粒、表面功能化白蛋白纳米颗粒和白蛋白纳米复合物。此外，在简要讨论了基于血清白蛋白的纳米载体作为纳米探针在癌症诊断中的应用后，我们还描述了基于血清白蛋白的纳米载体辅助癌症诊疗，包括气体治疗、化学动力学疗法（CDT）、光疗法（PTT/PDT）、声动力疗法（SDT）和其他疗法以及癌症成像。我们综述中引用的大量研究表明，基于血清白蛋白的纳米载体在癌症诊断和治疗应用中具有巨大潜力。
