School of Materials Science and Engineering, Shanghai Institute of Technology, Shanghai, 201418, China.
Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Colloids Surf B Biointerfaces. 2021 Mar;199:111508. doi: 10.1016/j.colsurfb.2020.111508. Epub 2020 Dec 4.
Nitric oxide (NO) is an important pharmaceutical agent of considerable therapeutic interest ascribed to its vasodilative, tumoricidal and antibacterial effects. Rapid development of functional nanomaterials has provided opportunities for us to achieve controllable exogenous delivery of NO. In the current review, a variety of functionalized colloidal nanovehicles that have been developed to date for nitric oxide delivery are reported. Specifically, we focus on inorganic nanomaterials such as semiconductor quantum dots, silica nanoparticles, upconversion nanomaterials, carbon/graphene nanodots, gold nanoparticles, iron oxide nanoparticles as the functional or/and supporting materials to carry NO donors. N-diazeniumdiolates, S-nitrosothiols, nitrosyl metal complexes and organic nitrates as main types of NO donors have their own unique properties and molecular structures. Conjugating the NO donors of different forms with appropriate nanomaterials results in NO delivery nanovehicles capable of releasing NO in a dose-controllable or/and on-demand manner. We also consider the therapeutic applications of those NO delivery nanovehicles, especially their applications for cancer therapy. In the end, we discuss possible future directions for developing exogenous NO delivery systems with more desired structure and improved performance. This review aims to offer the readers an overall view of the advances in functionalized colloidal nanovehicles for NO delivery. It will be attractive to scientists and researchers in the areas of material science, nanotechnology, biomedical engineering, chemical biology, etc.
一氧化氮（NO）是一种重要的药物制剂，具有血管扩张、杀肿瘤和抗菌作用，具有相当大的治疗价值。功能纳米材料的快速发展为我们实现可控的外源性一氧化氮输送提供了机会。在目前的综述中，报道了迄今为止为一氧化氮输送而开发的各种功能化胶体纳米载体。具体来说，我们专注于无机纳米材料，如半导体量子点、硅纳米颗粒、上转换纳米材料、碳/石墨烯纳米点、金纳米颗粒、氧化铁纳米颗粒，作为携带一氧化氮供体的功能或/和支撑材料。N-二亚氨基二硝酸盐、S-亚硝基硫醇、亚硝酰金属配合物和有机硝酸盐作为主要类型的一氧化氮供体具有独特的性质和分子结构。将不同形式的一氧化氮供体与合适的纳米材料结合，可以得到能够以剂量可控或/和按需方式释放一氧化氮的一氧化氮输送纳米载体。我们还考虑了这些一氧化氮输送纳米载体的治疗应用，特别是它们在癌症治疗中的应用。最后，我们讨论了开发具有更理想结构和改进性能的外源性一氧化氮输送系统的可能未来方向。本综述旨在为读者提供功能化胶体纳米载体在一氧化氮输送方面的进展的全面概述。它将吸引材料科学、纳米技术、生物医学工程、化学生物学等领域的科学家和研究人员的兴趣。
