Joshi Amit S
Department of Biochemistry and Cell and Molecular Biology, University of Tennessee, Knoxville, TN, United States.
Front Cell Dev Biol. 2021 Nov 19;9:735031. doi: 10.3389/fcell.2021.735031. eCollection 2021.
Peroxisomes are ubiquitous, single membrane-bound organelles that play a crucial role in lipid metabolism and human health. While peroxisome number is maintained by the division of existing peroxisomes, nascent peroxisomes can be generated from the endoplasmic reticulum (ER) membrane in yeasts. During formation and proliferation, peroxisomes maintain membrane contacts with the ER. In addition to the ER, contacts between peroxisomes and other organelles such as lipid droplets, mitochondria, vacuole, and plasma membrane have been reported. These membrane contact sites (MCS) are dynamic and important for cellular function. This review focuses on the recent developments in peroxisome biogenesis and the functional importance of peroxisomal MCS in yeasts.
过氧化物酶体是普遍存在的、由单层膜包裹的细胞器，在脂质代谢和人类健康中起着至关重要的作用。虽然过氧化物酶体的数量通过现有过氧化物酶体的分裂来维持，但在酵母中，新生的过氧化物酶体可以从内质网（ER）膜产生。在形成和增殖过程中，过氧化物酶体与内质网保持膜接触。除了内质网，过氧化物酶体与其他细胞器如脂滴、线粒体、液泡和质膜之间的接触也有报道。这些膜接触位点（MCS）是动态的，对细胞功能很重要。本综述重点关注酵母中过氧化物酶体生物发生的最新进展以及过氧化物酶体MCS的功能重要性。
