Wang Gengchen, Zhou Qian, Xu Yan, Zhao Baobing
Department of Pharmacology, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.
Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.
Front Cell Dev Biol. 2021 Nov 17;9:768238. doi: 10.3389/fcell.2021.768238. eCollection 2021.
Pleckstrin-2 is a member of pleckstrin family with well-defined structural features that was first identified in 1999. Over the past 20 years, our understanding of PLEK2 biology has been limited to cell spreading. Recently, increasing evidences support that PLEK2 plays important roles in other cellular events beyond cell spreading, such as erythropoiesis, tumorigenesis and metastasis. It serves as a potential diagnostic and prognostic biomarker as well as an attractive target for the treatment of cancers. Herein, we summary the protein structure and molecular interactions of pleckstrin-2, with an emphasis on its regulatory roles in tumorigenesis.
普列克底物蛋白-2是普列克底物蛋白家族的成员，具有明确的结构特征，于1999年首次被鉴定。在过去的20年里，我们对PLEK2生物学的理解仅限于细胞铺展。最近，越来越多的证据支持PLEK2在细胞铺展之外的其他细胞事件中发挥重要作用，如红细胞生成、肿瘤发生和转移。它可作为一种潜在的诊断和预后生物标志物，也是癌症治疗的一个有吸引力的靶点。在此，我们总结了普列克底物蛋白-2的蛋白质结构和分子相互作用，重点阐述其在肿瘤发生中的调控作用。
