Department of Obstetrics and Gynecology, The Third Xiangya Hospital of Central South University, Changsha, China.
Department of Geriatrics, The Third Xiangya Hospital of Central South University, Changsha, China.
J Immunol Res. 2021 Nov 22;2021:5578958. doi: 10.1155/2021/5578958. eCollection 2021.
As a transitional state between normal aging and Alzheimer's disease (AD), mild cognitive impairment (MCI) is characterized by a worse cognitive decline than that of natural aging. The association between AD and gut microbiota has been reported in a number of studies; however, microbial research regarding MCI remains limited.
This study examined 48 participants, of whom 22 were MCI cases and 26 were normal control cases. Fecal samples were collected for 16S ribosomal RNA (rRNA) quantitative arrays and bioinformatics analysis.
A principal coordinates analysis (PCoA) and nonmetric multidimensional scaling (NMDS) both demonstrated that the microbial composition of participants with MCI deviated from that of healthy control participants. Multiple bacterial species were significantly increased (e.g., ) or decreased (e.g., ) in samples from the MCI group.
The composition of gut microbiota differed between normal control and MCI cases. This is the first study to identify a signature series of species in the gut microbiota of individuals with MCI. The results provide a new direction for the future development of an early diagnosis and probiotic regimen.
轻度认知障碍（MCI）作为正常衰老和阿尔茨海默病（AD）之间的过渡状态，其认知能力下降比自然衰老更为严重。多项研究报道了 AD 与肠道微生物群之间的关联；然而，关于 MCI 的微生物研究仍然有限。
本研究纳入了 48 名参与者，其中 22 名是 MCI 病例，26 名是正常对照组。收集粪便样本进行 16S 核糖体 RNA（rRNA）定量阵列和生物信息学分析。
主坐标分析（PCoA）和非度量多维尺度分析（NMDS）均表明，MCI 参与者的微生物组成与健康对照组参与者的微生物组成不同。MCI 组样本中多种细菌种类显著增加（例如 ）或减少（例如 ）。
正常对照组和 MCI 组之间的肠道微生物组成存在差异。这是第一项鉴定 MCI 个体肠道微生物群中特征系列物种的研究。研究结果为未来开发早期诊断和益生菌方案提供了新的方向。
