Bergmann Karl-Christian, Berger Markus, Klimek Ludger, Pfaar Oliver, Werchan Barbora, Werchan Matthias, Zuberbier Torsten
Charité, Universitätsmedizin Berlin, Clinic for Dermatology, Venereology and Allergy, Berlin, Germany.
Institut für Pathophysiologie und Allergieforschung, Zentrum für Pathophysiologie, Infektiologie und Immunologie, Medizinische Universität Wien, Vienna, Austria.
Allergol Select. 2021 Dec 1;5:349-360. doi: 10.5414/ALX02294E. eCollection 2021.
Allergic rhinoconjunctivitis (hay fever) is the most common chronic disease in all industrialized nations. Therapy consists essentially in the use of anti-allergic and anti-inflammatory drugs, which mostly show a good and quick effect. With allergen-specific immunotherapy, there is also a causal possibility of tolerance induction. There is currently a considerable undersupply, as those affected trivialize the symptoms and often have concerns about long-term drug therapy. There is also great interest in using non-medicinal measures to prevent and/or relieve allergic symptoms on the assumption that these are free from side effects. In this publication, we present non-drug methods for which clinical studies are available in the literature. The methods have varying degrees of effectiveness. An evidence-based comparative assessment between the methods is not possible. There are also hardly any studies in comparison to standard drug therapy. A large number of the interventions consist of allergen reduction, e.g., with air filters, or cleaning of the mucous membranes with nasal irrigation, etc., none of which should be seen as a substitute but as a supplement to drug therapy.
变应性鼻结膜炎(花粉症)是所有工业化国家最常见的慢性疾病。治疗主要包括使用抗过敏和抗炎药物,这些药物大多显示出良好且快速的疗效。通过变应原特异性免疫疗法,也存在诱导耐受的病因学可能性。目前存在相当大的供应不足,因为患者轻视症状且常常对长期药物治疗有所顾虑。人们也对使用非药物措施来预防和/或缓解过敏症状有着浓厚兴趣,因为假定这些措施无副作用。在本出版物中,我们介绍了文献中有临床研究的非药物方法。这些方法的有效性程度各不相同。无法对这些方法进行基于证据的比较评估。与标准药物治疗相比,也几乎没有相关研究。大量干预措施包括减少变应原,例如使用空气过滤器,或通过鼻腔冲洗等清洁黏膜等,这些都不应被视为药物治疗的替代品,而应作为补充。