Rauch G
Methods Find Exp Clin Pharmacol. 1986 Mar;8(3):147-50.
Substance C [(+)-catechin; (+)-cyanidanol-3)], which has been used for liver therapy since 1976, showed efficient immunostimulating properties in studies undertaken to investigate its mode of action. The compound had a significant effect on activation of macrophages, cytotoxic-T-lymphocytes and natural killer cells in mice in a dose-dependent manner. It also inhibited leukocyte migration in the presence of an antigen by 10.5%. Substance C significantly increased spontaneous lymphocyte transformation and spontaneous pokeweed mitogen (PWM)- and Staphylococcus aureus Cowan I (SAC)-induced immunoglobulin synthesis in vitro. Furthermore, it exerted a stimulating effect on lymphocyte PHA-reactivity. In patients with HBV-positive chronic active hepatitis (CAH) it increased the ratio of OK4/OK8 cells. Its efficacy is comparable to that of the known immunostimulator inosine. The effect of cianidanol upon rosette formation in patients suffering from chronic liver diseases and healthy controls is qualitatively and quantitatively comparable to that of levamisole. The results of these studies are presented and discussed in regard to its efficacy in the therapy of HBsAG(+) and HBeAG(+) hepatitis.
物质C[（+）-儿茶素；（+）-氰定醇-3]自1976年以来一直用于肝脏治疗，在研究其作用方式的研究中显示出有效的免疫刺激特性。该化合物对小鼠巨噬细胞、细胞毒性T淋巴细胞和自然杀伤细胞的激活有显著的剂量依赖性作用。它还在抗原存在的情况下抑制白细胞迁移10.5%。物质C显著增加体外自发淋巴细胞转化以及自发美洲商陆有丝分裂原（PWM）和金黄色葡萄球菌考恩I（SAC）诱导的免疫球蛋白合成。此外，它对淋巴细胞PHA反应性有刺激作用。在HBV阳性慢性活动性肝炎（CAH）患者中，它增加了OK4/OK8细胞的比例。其疗效与已知免疫刺激剂肌苷相当。氰定醇对慢性肝病患者和健康对照者玫瑰花结形成的影响在定性和定量上与左旋咪唑相当。本文就其在HBsAG（+）和HBeAG（+）肝炎治疗中的疗效展示并讨论了这些研究结果。
