转化生长因子α抑制胃酸分泌。
Transforming growth factor alpha inhibits secretion of gastric acid.
作者信息
Rhodes J A, Tam J P, Finke U, Saunders M, Bernanke J, Silen W, Murphy R A
出版信息
Proc Natl Acad Sci U S A. 1986 Jun;83(11):3844-6. doi: 10.1073/pnas.83.11.3844.
Abstract
Transforming growth factor alpha (TGF-alpha), a protein secreted by transformed cells and related to epidermal growth factor (EGF), was tested for its effects on gastric acid secretion. Guinea pig gastric mucosae were mounted in Ussing chambers and the rate of acid release was monitored by the pH-stat method. When administered prior to the secretagogue, TGF-alpha prevented the histamine-induced increase in the rate of acid secretion. Similarly, TGF-alpha caused a decrease in the rate of acid release in tissues that had already been stimulated with histamine. These data show that TGF-alpha inhibits gastric acid secretion in a manner similar to EGF and that the two growth factors share at least one physiological action unrelated to their mitogenic properties.
摘要
转化生长因子α（TGF-α）是一种由转化细胞分泌的、与表皮生长因子（EGF）相关的蛋白质，对其胃酸分泌作用进行了测试。将豚鼠胃黏膜安装在尤斯灌流小室中，采用pH计法监测酸释放速率。在给予促分泌剂之前给予TGF-α，可阻止组胺诱导的胃酸分泌速率增加。同样，TGF-α可使已用组胺刺激过的组织中的酸释放速率降低。这些数据表明，TGF-α以类似于EGF的方式抑制胃酸分泌，并且这两种生长因子至少共享一种与其促有丝分裂特性无关的生理作用。
相似文献
1
Transforming growth factor alpha inhibits secretion of gastric acid.转化生长因子α抑制胃酸分泌。
Proc Natl Acad Sci U S A. 1986 Jun;83(11):3844-6. doi: 10.1073/pnas.83.11.3844.
2
Effects of epidermal growth factor on acid secretion from guinea pig gastric mucosa: in vitro analysis.表皮生长因子对豚鼠胃黏膜酸分泌的影响：体外分析
Gastroenterology. 1985 May;88(5 Pt 1):1175-82. doi: 10.1016/s0016-5085(85)80077-9.
3
Localization of transforming growth factor alpha and its receptor in gastric mucosal cells. Implications for a regulatory role in acid secretion and mucosal renewal.转化生长因子α及其受体在胃黏膜细胞中的定位。对胃酸分泌和黏膜更新调节作用的意义。
J Clin Invest. 1989 Sep;84(3):1017-23. doi: 10.1172/JCI114223.
4
Transforming growth factor-alpha and epidermal growth factor inhibit gastric acid secretion and stimulate release of somatostatin and neurotensin in the conscious rat.转化生长因子-α和表皮生长因子可抑制清醒大鼠的胃酸分泌，并刺激生长抑素和神经降压素的释放。
Regul Pept. 1994 Jul 14;52(2):111-8. doi: 10.1016/0167-0115(94)90043-4.
5
Epidermal growth factor (EGF) inhibits both intrinsic factor secretion and acid secretion in histamine-stimulated isolated gastric glands.表皮生长因子（EGF）抑制组胺刺激的离体胃腺中内因子的分泌和胃酸分泌。
Regul Pept. 1988 Jun;21(3-4):279-87. doi: 10.1016/0167-0115(88)90011-0.
6
Secretagogue-induced tachyphylaxis of gastric H + secretion and its reversal.促分泌素诱导的胃H⁺分泌快速耐受及其逆转
Am J Physiol. 1972 Aug;223(2):294-9. doi: 10.1152/ajplegacy.1972.223.2.294.
7
Inhibition of gastric acid secretion in dogs by neurotensin.
Life Sci. 1976 Aug 1;19(3):367-70. doi: 10.1016/0024-3205(76)90040-0.
8
Effects of histamine acid phosphate and pentagastrin on gastric secretion in normal human subjects.磷酸组胺和五肽胃泌素对正常人体受试者胃液分泌的影响。
Gut. 1970 May;11(5):395-404. doi: 10.1136/gut.11.5.395.
9
Epidermal growth factor inhibits cytoskeleton-related changes in the surface of parietal cells.表皮生长因子抑制壁细胞表面与细胞骨架相关的变化。
J Cell Biol. 1981 Jan;88(1):108-14. doi: 10.1083/jcb.88.1.108.
10
Increased production of transforming growth factor alpha following acute gastric injury.急性胃损伤后转化生长因子α的产生增加。
Gastroenterology. 1992 May;102(5):1467-74. doi: 10.1016/0016-5085(92)91703-7.
引用本文的文献
1
The Gastrointestinal Tract Is an Alternative Route for SARS-CoV-2 Infection in a Nonhuman Primate Model.胃肠道是 SARS-CoV-2 在非人类灵长类动物模型中感染的另一种途径。
Gastroenterology. 2021 Apr;160(5):1647-1661. doi: 10.1053/j.gastro.2020.12.001. Epub 2020 Dec 9.
2
Contribution of Wound-Associated Cells and Mediators in Orchestrating Gastrointestinal Mucosal Wound Repair.创面相关细胞和介质在调控胃肠道黏膜创面修复中的作用。
Annu Rev Physiol. 2019 Feb 10;81:189-209. doi: 10.1146/annurev-physiol-020518-114504. Epub 2018 Oct 24.
3
Sodium hydrosulfide upregulates mRNA and protein expression of TGF-α in gastric mucosa in experimental model of stimulated gastric acid secretion in rats.在大鼠胃酸分泌刺激实验模型中，氢硫化钠上调胃黏膜中转化生长因子-α（TGF-α）的mRNA和蛋白表达。
Iran J Basic Med Sci. 2017 Dec;20(12):1385-1389. doi: 10.22038/IJBMS.2017.9597.
4
Ménétrier's disease of the stomach: a clinical challenge.胃的梅内特里耶病：一项临床挑战。
Curr Gastroenterol Rep. 2011 Dec;13(6):513-7. doi: 10.1007/s11894-011-0222-8.
5
EGFR is involved in control of gastric cell proliferation through activation of MAPK and Src signalling pathways in early-weaned rats.表皮生长因子受体（EGFR）通过激活早期断奶大鼠的 MAPK 和 Src 信号通路，参与控制胃细胞的增殖。
Cell Prolif. 2011 Apr;44(2):174-82. doi: 10.1111/j.1365-2184.2011.00733.x.
6
Carbachol induces TGF-alpha expression and colonic epithelial cell proliferation in sensory-desensitised rats.卡巴胆碱诱导感觉脱敏大鼠转化生长因子-α表达和结肠上皮细胞增殖。
Int J Colorectal Dis. 2010 Mar;25(3):335-41. doi: 10.1007/s00384-009-0856-2. Epub 2009 Dec 10.
7
Inhibition of epidermal growth factor receptor activation enhances in vivo histamine-stimulated gastric acid secretion in the rat.抑制表皮生长因子受体激活可增强大鼠体内组胺刺激的胃酸分泌。
Dig Dis Sci. 2006 Feb;51(2):274-81. doi: 10.1007/s10620-006-3125-z.
8
Comparison of the antisecretory and antiulcer activity of epidermal growth factor, urogastrone and transforming growth factor alpha and its derivative in rodents in vivo.表皮生长因子、尿抑胃素、转化生长因子α及其衍生物在啮齿动物体内的抗分泌和抗溃疡活性比较
Mol Cell Biochem. 2002 Jul;236(1-2):83-94. doi: 10.1023/a:1016144016908.
9
Peptide gene expression in gastrointestinal mucosal ulceration: ordered sequence or redundancy?胃肠道黏膜溃疡中肽基因的表达：有序序列还是冗余？
Gut. 2000 Feb;46(2):286-92. doi: 10.1136/gut.46.2.286.
10
Immunolocalization of transforming growth factor-alpha and epidermal growth factor receptor in the rat gastroduodenal area.转化生长因子-α和表皮生长因子受体在大鼠胃十二指肠区域的免疫定位
Dig Dis Sci. 1999 Jul;44(7):1408-16. doi: 10.1023/a:1026655903294.
本文引用的文献
1
Murine sarcoma growth factors affect the growth and morphology of cultured mouse epithelial cells.
J Cell Physiol. 1980 Jul;104(1):41-6. doi: 10.1002/jcp.1041040107.
2
Role of mucosal prostaglandins and DNA synthesis in gastric cytoprotection by luminal epidermal growth factor.黏膜前列腺素和DNA合成在腔内表皮生长因子对胃细胞保护中的作用。
Gut. 1981 Nov;22(11):927-32. doi: 10.1136/gut.22.11.927.
3
Gastric cytoprotection by epidermal growth factor. Role of endogenous prostaglandins and DNA synthesis.表皮生长因子对胃的细胞保护作用。内源性前列腺素和DNA合成的作用。
Gastroenterology. 1981 Sep;81(3):438-43.
4
Epidermal growth factor inhibits cytoskeleton-related changes in the surface of parietal cells.表皮生长因子抑制壁细胞表面与细胞骨架相关的变化。
J Cell Biol. 1981 Jan;88(1):108-14. doi: 10.1083/jcb.88.1.108.
5
6
Sarcoma growth factor from conditioned medium of virally transformed cells is composed of both type alpha and type beta transforming growth factors.病毒转化细胞条件培养基中的肉瘤生长因子由α型和β型转化生长因子组成。
Proc Natl Acad Sci U S A. 1983 Oct;80(20):6264-8. doi: 10.1073/pnas.80.20.6264.
7
Synthesis of biologically active rat transforming growth factor I.具有生物活性的大鼠转化生长因子I的合成
Nature. 1984;309(5966):376-8. doi: 10.1038/309376a0.
8
Vaccinia virus 19-kilodalton protein: relationship to several mammalian proteins, including two growth factors.痘苗病毒19千道尔顿蛋白：与几种哺乳动物蛋白的关系，包括两种生长因子。
Proc Natl Acad Sci U S A. 1984 Dec;81(23):7363-7. doi: 10.1073/pnas.81.23.7363.
9
Rat transforming growth factor type 1: structure and relation to epidermal growth factor.大鼠转化生长因子1型：结构及其与表皮生长因子的关系。
Science. 1984 Mar 9;223(4640):1079-82. doi: 10.1126/science.6320373.
10
Antibodies to the epidermal growth factor receptor block the biological activities of sarcoma growth factor.表皮生长因子受体抗体可阻断肉瘤生长因子的生物学活性。
Proc Natl Acad Sci U S A. 1983 Sep;80(18):5627-30. doi: 10.1073/pnas.80.18.5627.
Zotero 插件