表皮生长因子抑制壁细胞表面与细胞骨架相关的变化。
Epidermal growth factor inhibits cytoskeleton-related changes in the surface of parietal cells.
作者信息
González A, Garrido J, Vial J D
出版信息
J Cell Biol. 1981 Jan;88(1):108-14. doi: 10.1083/jcb.88.1.108.
Abstract
The effect of epidermal growth factor (EGF) on gastric acid secretion was correlated with the morphological changes of the apical pole of rat parietal cells studied by transmission electron microscopy. Gastric acid secretion was stimulated by histamine, carbachol, pentagastrin, and insulin-induced hypoglycemia, and estimated by continuous recording of pH variations of gastric luminal perfusate. EGF inhibits acid secretion in these conditions. The action of the hormone also results in the arrest or reversal of the changes in shape undergone by parietal cells as they go into secretion. In view of the evidence involving cytoskeletal elements in the generation of these structural alterations, our observations suggest that the action of EGF on gastric acid secretion may be a consequence of a general effect of this hormone on cytoskeletal function.
摘要
通过透射电子显微镜研究了表皮生长因子（EGF）对胃酸分泌的影响，并将其与大鼠壁细胞顶端的形态变化相关联。组胺、卡巴胆碱、五肽胃泌素和胰岛素诱导的低血糖刺激胃酸分泌，并通过连续记录胃腔灌流液的pH变化来评估。在这些情况下，EGF抑制胃酸分泌。该激素的作用还导致壁细胞在分泌过程中所经历的形状变化停止或逆转。鉴于有证据表明细胞骨架成分参与了这些结构改变的产生，我们的观察结果表明，EGF对胃酸分泌的作用可能是该激素对细胞骨架功能的一般作用的结果。
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