Uter Wolfgang, Johansen Jeanne D, Havmose Martin S, Kezic Sanja, van der Molen Henk F, Macan Jelena, Babić Željka, Turk Rajka, Symanzik Cara, John Swen M
Department of Medical Informatics, Biometry and Epidemiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
National Allergy Research Centre, Department of Skin and Allergy, Gentofte Hospital, University of Copenhagen, Kobenhavn, Denmark.
BMJ Open. 2021 Dec 6;11(12):e050612. doi: 10.1136/bmjopen-2021-050612.
Hairdressers constitute a major subgroup in the service sector. They are exposed to various substances hazardous for skin, airways or systemically. Accordingly, skin and other occupational diseases are common. The present systematic review will compile and appraise evidence regarding skin, systemic and airways toxicity of an indicative set of specific, important product ingredients. Additionally, evidence concerning hand eczema morbidity among hairdressers will be reviewed.
Systematic searches will be performed in two electronic literature databases (Medline, Web of Science-Core Collection), the Cochrane register and two collections of toxicological dossiers (Scientific Committee on Consumer Safety of the European Commission and the MAK Commission of the German Research Council). Additional literature sources will be retrieved using hand search of reference lists of included studies and snowballing methods. We will include studies with all types of quantitative study designs, including results from in vitro and in vivo experiments, chemical analysis, epidemiological findings and clinical results. We will assess the risk of bias within studies amalgamating an abbreviated version of the Mixed Methods Appraisal Tool, basic Cochrane criteria and US Environmental Protection Agency assessment factors for scientific information. As we expect large heterogeneity in methods and outcomes, we will conduct a narrative synthesis of results instead of a meta-analysis, except where quantitative pooling is feasible.
Ethical approval and patient consent are not required as this is a systematic review based on published studies. The results of this study will be published in international peer-reviewed journals.
CRD42021238118.
美发师是服务业的一个主要子群体。他们接触到各种对皮肤、呼吸道或全身有害的物质。因此，皮肤和其他职业病很常见。本系统综述将汇编和评估关于一组特定的重要产品成分的皮肤、全身和呼吸道毒性的证据。此外，还将综述美发师手部湿疹发病率的相关证据。
将在两个电子文献数据库（Medline、Web of Science核心合集）、Cochrane注册库以及两个毒理学档案集（欧盟委员会消费者安全科学委员会和德国研究理事会的MAK委员会）中进行系统检索。将通过手工检索纳入研究的参考文献列表和滚雪球法检索其他文献来源。我们将纳入所有类型定量研究设计的研究，包括体外和体内实验结果、化学分析、流行病学研究结果和临床结果。我们将采用混合方法评估工具的简化版、基本的Cochrane标准和美国环境保护局科学信息评估因素，综合评估研究中的偏倚风险。由于我们预计方法和结果存在较大异质性，因此除了可行的定量合并外，我们将对结果进行叙述性综合，而不是进行荟萃分析。
由于这是一项基于已发表研究的系统综述，因此无需伦理批准和患者同意。本研究结果将发表在国际同行评审期刊上。
PROSPERO注册号：CRD42021238118。
