Wagner V, Wagnerová M, Wokounová D, Kriz J, Mádlo Z, Mohyla O
J Hyg Epidemiol Microbiol Immunol. 1981;25(2):97-12.
Ninety children residing in a highly Pb-polluted area near a lead foundry (group E), and 61 children from the control area (group C) were examined and compared. In group E children there were detected significantly increased blood Pb concentrations (girls: 31.6 +/- 16 microgram/100 ml; boys: 38.7 +/- 15.8 microgram/100 ml) in comparison with the control group C children (about 20 microgram/100 ml for both sexes). Regression analysis revealed significantly positive correlation of Pb concentrations in blood with the level of total blood proteins and ALAD, the correlation with A-1AT, alpha-2-M, TRF, and CPL was much less pronounced. Also the correlation of Ca2+ concentrations in blood with blood protein levels was not too marked. On the other hand, the age factor turned out to be very influencing in girls. Remarkable was the change of Pb and Ca correlation positivity in group C children to correlation negativity in group E (ALAD, total proteins, CPL), or of correlation negativity to correlation positivity (A-1AT, TRF). The observed changes are discussed from the aspect of multifactorial action of Pb in the organism.
对居住在铅冶炼厂附近铅污染严重地区的90名儿童（E组）和来自对照区的61名儿童（C组）进行了检查和比较。与对照组C组儿童（男女均约为20微克/100毫升）相比，E组儿童的血铅浓度显著升高（女孩：31.6±16微克/100毫升；男孩：38.7±15.8微克/100毫升）。回归分析显示，血铅浓度与总血蛋白和ALAD水平呈显著正相关，与A-1AT、α-2-M、TRF和CPL的相关性则不太明显。此外，血钙浓度与血蛋白水平的相关性也不太显著。另一方面，年龄因素对女孩的影响非常大。值得注意的是，C组儿童中铅与钙的相关性由正变为E组中的负相关（ALAD、总蛋白、CPL），或由负相关变为正相关（A-1AT、TRF）。从铅在生物体内的多因素作用方面对观察到的变化进行了讨论。
