Zhai Duan-Yang, Zhen Tian-Tian, Zhang Xiao-Ling, Luo Jia, Shi Hui-Juan, Shi Ya-Wei, Shao Nan
The Breast Disease Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510000, Guangdong Province, China.
Department of Pathology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510000, Guangdong Province, China.
World J Clin Cases. 2021 Nov 6;9(31):9549-9556. doi: 10.12998/wjcc.v9.i31.9549.
Malignant adenomyoepithelioma (AME) of the breast is a rare tumor in which malignancy can arise from either epithelial or myoepithelial components, or from both cell types. The incidence and prognosis of malignant AME of the breast are difficult to assess due to its rarity. Therefore, the optimal treatment for this disease is still controversial.
We present two middle-aged women (48 and 56 years old) with malignant AME of the breast. Core needle biopsy was performed before surgery. However, breast adenoma and malignant tumors were observed. The preoperative diagnosis of malignant AME of the breast is still challenging for pathologists and clinicians. Both patients underwent mastectomy and sentinel lymph node biopsy, both of which were negative, followed by adjuvant chemotherapy.
The follow-up duration of the two patients was two years and four months, respectively. No signs of relapse or metastasis have been observed thus far.
乳腺恶性腺肌上皮瘤（AME）是一种罕见肿瘤，其恶性可源于上皮成分或肌上皮成分，或源于两种细胞类型。由于其罕见性，乳腺恶性AME的发病率和预后难以评估。因此，该病的最佳治疗方法仍存在争议。
我们报告两名患有乳腺恶性AME的中年女性（分别为48岁和56岁）。术前进行了粗针活检。然而，观察到乳腺腺瘤和恶性肿瘤。乳腺恶性AME的术前诊断对病理学家和临床医生来说仍然具有挑战性。两名患者均接受了乳房切除术和前哨淋巴结活检，结果均为阴性，并随后接受了辅助化疗。
两名患者的随访时间分别为两年零四个月。迄今为止，未观察到复发或转移迹象。
