Yuan Zhu, Qu Xiang, Zhang Zhong-Tao, Jiang Wen G
Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Cardiff China Medical Research Collaborative, Cardiff University, School of Medicine, Heath Park, Cardiff, CF14 4XN, UK.
World J Oncol. 2017 Aug;8(4):126-131. doi: 10.14740/wjon1055e. Epub 2017 Aug 27.
This study set out to investigate the clinical diagnosis and treatment strategies for malignant breast adenomyoepithelioma (AME), thus increasing the clinical knowledge on such disease. Two patients with malignant breast AME in Beijing Friendship Hospital were selected for study. Here we report the diagnosis and treatment processes in terms of the failure experience and lessons and relate our findings to those in the literature. Malignant breast AME is inclined to affect the areola area. It is recommended to conduct simple mastectomy combined with sentinel lymph node dissection due to the low sensitivity of the preoperative imaging diagnosis and difficulty in the pathological diagnosis. Malignant breast AME features strong invasiveness and vulnerability to recurrence and metastasis. Therefore, the operative schemes and clinical treatment strategies should be formulated based on the comprehensive analyses of the physical signs, imageological examinations and pathology.
本研究旨在探讨乳腺恶性腺肌上皮瘤（AME）的临床诊断及治疗策略，从而增加对该疾病的临床认识。选取北京友谊医院2例乳腺恶性AME患者进行研究。在此，我们根据失败的经验教训报告诊断和治疗过程，并将我们的发现与文献中的发现进行关联。乳腺恶性AME倾向于累及乳晕区。由于术前影像学诊断敏感性低且病理诊断困难，建议行单纯乳房切除术联合前哨淋巴结清扫术。乳腺恶性AME具有较强的侵袭性，易复发和转移。因此，应基于对体征、影像学检查和病理的综合分析来制定手术方案和临床治疗策略。
