Artificial Intelligence for Automated Cancer Detection on Prostate MRI: Opportunities and Ongoing Challenges, From the Special Series on AI Applications.

Use of prostate MRI has increased greatly in the past decade, primarily in directing targeted prostate biopsy. However, prostate MRI interpretation remains prone to interreader variation. Artificial intelligence (AI) has the potential to standardize detection of lesions on MRI that are suspicious for prostate cancer (PCa). The purpose of this review is to explore the current status of AI for the automated detection of PCa on MRI. Recent literature describing promising results regarding AI models for PCa detection on MRI is highlighted. Numerous limitations of the existing literature are also described, including biases in model validation, heterogeneity in reporting of performance metrics, and lack of sufficient evidence of clinical translation. Challenges related to AI ethics and data governance are also discussed. An outlook is provided for AI in lesion detection on prostate MRI in the coming years, emphasizing current research needs. Future investigations, incorporating large-scale diverse multiinstitutional training and testing datasets, are anticipated to enable the development of more robust AI models for PCa detection on MRI, though prospective clinical trials will ultimately be required to establish benefit of AI in patient management.