Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil.
School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia.
Cad Saude Publica. 2021 Dec 1;37(11):e00152021. doi: 10.1590/0102-311X00152021. eCollection 2021.
Evolving evidence shows that ultra-processed food consumption may increase exposure to chemicals used in food packaging and production, such as per- and poly-fluoroalkyl substances, phthalates, and bisphenols. Studies suggested that these contaminants may be transferred from mother to child through placenta, increasing concerns for both maternal and child health. This study aimed to investigate the association of maternal consumption of ultra-processed foods with newborn exposure to perfluoroalkyl substances (PFAS) in the PIPA Project (The Rio Birth Cohort Study on Environmental Exposure and Childhood Development). The pilot cohort study conducted with 131 pregnant women-child pairs in a public maternity school in Rio de Janeiro, Brazil, was assessed. Maternal dietary intake in the third trimester of pregnancy was evaluated using a qualitative food frequency questionnaire. Food items were classified as non-ultra-processed food and ultra-processed food using the NOVA system and regular consumption of ultra-processed foods was estimated. Newborns of pregnant women who weekly consumed three or more subgroups of ultra-processed food presented the highest level of PFAS (2.47ng/mL; 95%CI: 1.22; 3.72), compared to non-consumption of ultra-processed food investigated (0 ultra-processed food = 1.86ng/mL; 95%CI: 1.38; 2.50). Additionally, cluster analysis grouped ultra-processed food, fish, and PFAS levels. In conclusion, we found increased levels of PFAS in newborns whose mothers were higher consumers of ultra-processed foods.
不断发展的证据表明，超加工食品的消费可能会增加接触食品包装和生产中使用的化学物质的机会，如全氟和多氟烷基物质、邻苯二甲酸酯和双酚。研究表明，这些污染物可能通过胎盘从母亲转移到孩子身上，这引起了对母婴健康的关注。本研究旨在调查 PIPA 项目（里约环境暴露与儿童发育出生队列研究）中母亲食用超加工食品与新生儿暴露于全氟烷基物质 (PFAS) 之间的关联。该试点队列研究在巴西里约热内卢的一所公立妇产医院对 131 对孕妇-儿童进行了评估。在妊娠晚期，使用定性食物频率问卷评估了孕妇的饮食摄入量。使用 NOVA 系统将食物分为非超加工食品和超加工食品，并估计了超加工食品的常规消费。与未食用超加工食品的孕妇相比（每周食用三种或更多亚组的超加工食品的孕妇），每周食用三种或更多亚组的超加工食品的孕妇所生新生儿的 PFAS 水平最高（2.47ng/mL；95%CI：1.22；3.72）（0 超加工食品=1.86ng/mL；95%CI：1.38；2.50）。此外，聚类分析将超加工食品、鱼类和 PFAS 水平进行了分组。总之，我们发现，母亲食用超加工食品较多的新生儿体内的 PFAS 水平升高。
