Clinical Research Platform for Interdiscipline of Stomatology, The First Affiliated Hospital of Jinan University, Department of Stomatology, College of stomatology, Jinan University, Guangzhou, China.
Science and Education Office, The First Affiliated Hospital, Jinan University, Guangzhou, China.
J Periodontal Res. 2022 Apr;57(2):246-255. doi: 10.1111/jre.12958. Epub 2021 Dec 8.
Periodontopathic bacteria constantly stimulate the host, which causes an immune response, leading to host-induced periodontal tissue damage. The complex interaction and imbalance between Th17 and Treg cells may be critical in the pathogenesis of periodontitis. Furthermore, the RANKL/RANK/OPG system plays a significant role in periodontitis bone metabolism, and its relationship with the Th17/Treg cell imbalance may be a bridge between periodontal bone metabolism and the immune system. This article reviews the literature related to the Th17/Treg cell imbalance mediated by pathogenic periodontal microbes, and its mechanism involving RANKL/RANK/OPG in periodontitis bone metabolism, in an effort to provide new ideas for the study of the immunopathological mechanism of periodontitis.
牙周致病菌持续刺激宿主，引发免疫反应，导致宿主诱导的牙周组织损伤。Th17 和 Treg 细胞之间的复杂相互作用和失衡可能在牙周炎的发病机制中起关键作用。此外，RANKL/RANK/OPG 系统在牙周炎骨代谢中发挥重要作用，其与 Th17/Treg 细胞失衡的关系可能是牙周骨代谢与免疫系统之间的桥梁。本文就牙周致病菌介导的 Th17/Treg 细胞失衡及其在牙周炎骨代谢中涉及 RANKL/RANK/OPG 的机制相关文献进行综述，以期为牙周炎的免疫病理机制研究提供新思路。
