State Key Laboratory of Luminescence and Applications, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun, 130033 Jilin, China.
University of the Chinese Academy of Sciences, Beijing 100049, China.
ACS Nano. 2021 Dec 28;15(12):20643-20655. doi: 10.1021/acsnano.1c09635. Epub 2021 Dec 8.
Photodynamic therapy (PDT) has been widely used in tumor therapy due to its high spatial-temporal control and noninvasiveness. However, its clinical application is limited by weak efficacy, shallow tissue penetration, and phototoxicity. Herein, a facile theranostic nanoplatform based on photoswitchable lanthanide-doped nanoparticles was designed. Typically, these nanoparticles had UV-blue and 1525 nm emission upon 980 nm excitation and 1525 nm emission upon 800 nm excitation. We further used these nanoparticles for achieving real-time near-infrared (NIR)-IIb imaging (800 nm) with a high signal-to-noise ratio and imaging-guided PDT (980 nm). Moreover, such a photoswitchable nanoplatform capping with pH-sensitive calcium phosphate for coloading doxorubicin (a chemotherapeutic immunogenic cell death [ICD] inducer) and paramagnetic Mn ions enhances T-magnetic resonance imaging in the tumor microenvironment. Our results suggest that this theranostic nanoplatform could not only kill tumor cells directly through dual-modal image-guided PDT/chemotherapy but also inhibit distant tumor and lung metastasis through ICD. Therefore, it has great potential for clinical application .
光动力疗法（PDT）由于其时空控制精度高和非侵入性，已被广泛应用于肿瘤治疗。然而，其临床应用受到疗效弱、组织穿透浅和光毒性的限制。在此，设计了一种基于可光开关镧系掺杂纳米粒子的简便治疗性纳米平台。通常，这些纳米粒子在 980nm 激发时具有 UV-蓝光和 1525nm 发射，在 800nm 激发时具有 1525nm 发射。我们进一步使用这些纳米粒子实现了实时近红外（NIR）-IIb 成像（800nm），具有高信噪比和成像引导的 PDT（980nm）。此外，这种可光开关的纳米平台用 pH 敏感的磷酸钙进行封装，用于共载多柔比星（一种化疗免疫原性细胞死亡[ICD]诱导剂）和顺磁性 Mn 离子，增强了肿瘤微环境中的 T 磁共振成像。我们的结果表明，这种治疗性纳米平台不仅可以通过双模态图像引导 PDT/化疗直接杀死肿瘤细胞，还可以通过 ICD 抑制远处肿瘤和肺转移。因此，它具有很大的临床应用潜力。
