Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-Ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.
University of Ulsan College of Medicine, Seoul, South Korea.
Sci Rep. 2021 Dec 8;11(1):23700. doi: 10.1038/s41598-021-03175-1.
Sarcoidosis is a systemic granulomatous disorder of unknown cause involving multiple organs. Its clinical presentation and prognosis vary among races. We identified the clinical characteristics and outcomes of Korean patients with sarcoidosis. Clinical data of 367 Korean patients with biopsy-proven sarcoidosis diagnosed in 2001-2017 were retrospectively analyzed. Treatment responses included improvement, stability, or progression based on changes in pulmonary sarcoidosis on chest images. The mean age was 47.4 years, and 67.3% of patients were women. The median follow-up period was 80 months. The highest prevalence was observed in individuals aged 50-59 years (30-39 years in men, 50-59 years in women), and the number of diagnoses showed an increasing trend. Lung involvement was the most common (93.5%), followed by the skin, eyes, and extrathoracic lymph nodes. Among patients with lung involvement and a follow-up period of ≥ 3 months, 66.8%, 31.0%, and 2.2% showed improvement, stability, and progression, respectively. Eleven patients (2.9%) died, and the 5-year survival rate was 99%. The number of diagnosed cases showed an increasing trend, and the mean age at diagnosis was increased compared with that in previous reports. Organ involvement was similar to that of Westerners, although the prognosis appeared better.
结节病是一种原因不明的系统性肉芽肿性疾病，涉及多个器官。其临床表现和预后在不同种族之间存在差异。我们确定了韩国结节病患者的临床特征和结局。回顾性分析了 2001 年至 2017 年间经活检证实的 367 例韩国结节病患者的临床资料。治疗反应根据胸部图像上的肺结节病变化分为改善、稳定或进展。患者的平均年龄为 47.4 岁，67.3%为女性。中位随访时间为 80 个月。发病率最高的年龄段为 50-59 岁（男性为 30-39 岁，女性为 50-59 岁），且诊断数量呈上升趋势。肺部受累最常见（93.5%），其次是皮肤、眼睛和胸外淋巴结。在有肺部受累且随访时间≥3 个月的患者中，分别有 66.8%、31.0%和 2.2%的患者病情改善、稳定和进展。11 例（2.9%）患者死亡，5 年生存率为 99%。诊断病例数量呈上升趋势，与以往报告相比，诊断时的平均年龄有所增加。器官受累与西方人相似，尽管预后似乎更好。
