Beijing Key Laboratory of Plant Resource Research and Development, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing, People's Republic of China.
Institute of Cosmetic Regulatory Science, Beijing Technology and Business University, Beijing, People's Republic of China.
Drug Des Devel Ther. 2021 Dec 1;15:4901-4909. doi: 10.2147/DDDT.S337524. eCollection 2021.
Damage caused by oxidative stress leads to the premature aging of cells. Mogrosides, the main active components of , have strong antioxidant activity; however, it is unclear whether mogroside V (MV) exerts these effects in skin cells. This was investigated in the present study by evaluating the protective effects of MV against oxidative damage induced by hydrogen peroxide (HO) in skin fibroblasts.
Mouse skin fibroblasts (MSFs) were treated with HO and cell viability, total antioxidant capacity, reactive oxygen species (ROS) production, malondialdehyde (MDA) content, and antioxidant enzyme activity were assessed.
Treatment with MV reduced the ROS level and MDA content in MSFs treated with HO. This was accompanied by increased superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) activities.
MV reduces HO-induced oxidative stress and enhances endogenous antioxidant activity in skin fibroblasts. Thus, MV can potentially be used as an ingredient in anti-aging cosmetic products.
氧化应激导致的细胞损伤会加速细胞衰老。罗汉果苷，为 的主要活性成分，具有很强的抗氧化活性；然而，其是否在皮肤细胞中发挥作用尚不清楚。本研究通过评估 MV 对过氧化氢（HO）诱导的皮肤成纤维细胞氧化损伤的保护作用，对此进行了研究。
用 HO 处理小鼠皮肤成纤维细胞（MSFs），并评估细胞活力、总抗氧化能力、活性氧（ROS）产生、丙二醛（MDA）含量和抗氧化酶活性。
MV 处理可降低 HO 处理的 MSFs 中的 ROS 水平和 MDA 含量。这伴随着超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）和过氧化氢酶（CAT）活性的增加。
MV 可减少 HO 诱导的氧化应激并增强皮肤成纤维细胞内源性抗氧化活性。因此，MV 可作为抗衰老化妆品的成分。
