类风湿关节炎患者的骨代谢
Bone metabolism in patients with rheumatoid arthritis.
作者信息
Bijlsma J W
机构信息
Department of Rheumatology, University Hospital Utrecht, The Netherlands.
出版信息
Clin Rheumatol. 1988 Mar;7(1):16-23. doi: 10.1007/BF02284051.
PMID:3044670
Abstract
Bone metabolism in patients with rheumatoid arthritis is reviewed. Two different entities are recognised: 1) a localised periarticular bone loss, due to inflammatory processes and 2) a generalised increased bone turnover, ultimately leading to a loss of axial bone mass. The mechanism of this loss of axial bone is not completely understood; probably immobilisation is the most important factor. The influence of certain drugs is discussed.
摘要
本文综述了类风湿性关节炎患者的骨代谢情况。目前认识到两种不同的情况：1）由于炎症过程导致的局部关节周围骨质流失；2）全身性骨转换增加，最终导致轴向骨量流失。轴向骨量流失的机制尚未完全明确；固定不动可能是最重要的因素。文中还讨论了某些药物的影响。
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