Division of Neurosurgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 804201, Taiwan.
Int J Mol Sci. 2021 Nov 29;22(23):12913. doi: 10.3390/ijms222312913.
The proliferation of drug-resistant pathogens continues to increase, giving rise to serious public health concerns. Many researchers have formulated metal oxide nanoparticles for use as novel antibacterial agents. In the present study, copper oxide (CuO) was synthesized by simple hydrothermal synthesis, and doping was performed to introduce different polymers onto the NP surface for bacteriostasis optimization. The polymer-modified CuO NPs were analyzed further with XRD, FTIR, TEM, DLS and zeta potential to study their morphology, size, and the charge of the substrate. The results indicate that polymer-modified CuO NPs had a significantly higher bacteriostatic rate than unmodified CuO NPs. In particular, polydopamine (PDA)-modified CuO (CuO-PDA) NPs, which carry a weakly negative surface charge, exhibited excellent antibacterial effects, with a bacteriostatic rate of up to 85.8 ± 0.2% within 3 h. When compared to other polymer-modified CuO NPs, CuO-PDA NPs exhibited superior bacteriostatic activity due to their smaller size, surface charge, and favorable van der Waals interactions. This may be attributed to the fact that the CuO-PDA NPs had relatively lipophilic structures at pH 7.4, which increased their affinity for the lipopolysaccharide-containing outer membrane of the Gram-negative bacterium
耐药病原体的不断增加引发了严重的公共卫生问题。许多研究人员已经将金属氧化物纳米粒子制成新型抗菌剂。在本研究中，通过简单的水热合成合成了氧化铜 (CuO)，并进行掺杂，在 NP 表面引入不同的聚合物以优化抑菌效果。对聚合物修饰的 CuO NPs 进行了进一步的 XRD、FTIR、TEM、DLS 和 ζ 电位分析，以研究其形态、尺寸和基底的电荷。结果表明，聚合物修饰的 CuO NPs 的抑菌率明显高于未修饰的 CuO NPs。特别是具有弱负表面电荷的聚多巴胺 (PDA) 修饰的 CuO (CuO-PDA) NPs 表现出优异的抗菌效果，在 3 h 内抑菌率高达 85.8±0.2%。与其他聚合物修饰的 CuO NPs 相比，CuO-PDA NPs 具有更高的抑菌活性，因为其尺寸更小、表面电荷和有利的范德华相互作用。这可能是因为在 pH 7.4 时，CuO-PDA NPs 具有相对亲脂的结构，增加了它们与革兰氏阴性菌外膜中含脂多糖的亲和力。
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