Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
The Collaborative InnovAffiliated Hospital of Zunyi Medical Universityation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, China.
J Cell Mol Med. 2024 Apr;28(7):e18154. doi: 10.1111/jcmm.18154.
Dopamine (DA) is a neurotransmitter synthesized in the human body that acts on multiple organs throughout the body, reaching them through the blood circulation. Neurotransmitters are special molecules that act as messengers by binding to receptors at chemical synapses between neurons. As ligands, they mainly bind to corresponding receptors on central or peripheral tissue cells. Signalling through chemical synapses is involved in regulating the activities of various body systems. Lack of DA or a decrease in DA levels in the brain can lead to serious diseases such as Parkinson's disease, schizophrenia, addiction and attention deficit disorder. It is widely recognized that DA is closely related to neurological diseases. As research on the roles of brain-gut peptides in human physiology and pathology has deepened in recent years, the regulatory role of neurotransmitters in digestive system diseases has gradually attracted researchers' attention, and research on DA has expanded to the field of digestive system diseases. This review mainly elaborates on the research progress on the roles of DA and DRs related to digestive system diseases. Starting from the biochemical and pharmacological properties of DA and DRs, it discusses the therapeutic value of DA- and DR-related drugs for digestive system diseases.
多巴胺（DA）是人体内合成的一种神经递质，作用于全身多个器官，通过血液循环到达这些器官。神经递质是特殊的分子，通过与神经元之间化学突触的受体结合，充当信使。作为配体，它们主要与中枢或外周组织细胞上相应的受体结合。通过化学突触的信号传递参与调节各种身体系统的活动。大脑中缺乏 DA 或 DA 水平降低会导致严重疾病，如帕金森病、精神分裂症、成瘾和注意力缺陷障碍。人们普遍认为 DA 与神经疾病密切相关。近年来，随着对脑-肠肽在人体生理和病理中作用的研究不断深入，神经递质在消化系统疾病中的调节作用逐渐引起研究人员的关注，对 DA 的研究也扩展到消化系统疾病领域。本文主要阐述了 DA 和与消化系统疾病相关的 DR 作用的研究进展。本文从 DA 和 DR 的生化和药理学特性出发，讨论了与 DA 和 DR 相关的药物治疗消化系统疾病的治疗价值。
