Department of Oncology and Haematology, General Hospital Pula, Santorijeva 24a, 52100 Pula, Croatia.
Faculty of Medicine, Juraj Dobrila University of Pula, Zagrebačka 30, 52100 Pula, Croatia.
Int J Mol Sci. 2021 Nov 30;22(23):12980. doi: 10.3390/ijms222312980.
Cancer is one of the most important global health problems that continues to demand new treatment strategies. Many bacteria that cause persistent infections play a role in carcinogenesis. However, since bacteria are well studied in terms of molecular mechanisms, they have been proposed as an interesting solution to treat cancer. In this review, we present the use of bacteria, and particularly bacterial toxins, in cancer therapy, highlighting the advantages and limitations of bacterial toxins. Proteomics, as one of the omics disciplines, is essential for the study of bacterial toxins. Advances in proteomics have contributed to better characterization of bacterial toxins, but also to the development of anticancer drugs based on bacterial toxins. In addition, we highlight the current state of knowledge in the rapidly developing field of bacterial extracellular vesicles, with a focus on their recent application as immunotherapeutic agents.
癌症是全球最重要的健康问题之一，不断需要新的治疗策略。许多导致持续感染的细菌在致癌作用中发挥作用。然而，由于细菌在分子机制方面的研究已经很深入，因此它们被提出作为治疗癌症的一种有趣的解决方案。在这篇综述中，我们介绍了细菌，特别是细菌毒素在癌症治疗中的应用，强调了细菌毒素的优势和局限性。蛋白质组学作为组学学科之一，对于细菌毒素的研究至关重要。蛋白质组学的进步不仅有助于更好地描述细菌毒素，还为基于细菌毒素的抗癌药物的开发做出了贡献。此外，我们还强调了细菌细胞外囊泡这一快速发展领域的最新知识状态，重点介绍了它们作为免疫治疗剂的最新应用。
Zotero 插件