抗原与半抗原特异性B细胞结合后c-myc原癌基因的诱导。
Induction of the c-myc protooncogene after antigen binding to hapten-specific B cells.
作者信息
Snow E C, Fetherston J D, Zimmer S
出版信息
J Exp Med. 1986 Sep 1;164(3):944-9. doi: 10.1084/jem.164.3.944.
Abstract
The stimulation of hapten-specific B cell populations with the thymus-dependent antigen, TNP-KLH, was found to induce elevated levels of c-myc mRNA by 2 h. A similar treatment with carrier protein alone did not elevate c-myc mRNA above the level seen in the nonstimulated, resting B cells. These results indicate that antigen binding to the sIg receptor, in the absence of Th cell involvement, directly signals the antigen-binding cell and implicates the active participation of sIg during the process of antigen-mediated B cell activation.
摘要
研究发现，用胸腺依赖性抗原TNP-KLH刺激半抗原特异性B细胞群体，2小时后c-myc mRNA水平升高。单独用载体蛋白进行类似处理，c-myc mRNA水平并未高于未刺激的静止B细胞中的水平。这些结果表明，在没有Th细胞参与的情况下，抗原与sIg受体结合直接向抗原结合细胞发出信号，提示sIg在抗原介导的B细胞激活过程中发挥了积极作用。
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