Ortiz V, Klein L, Channell S, Simpson B, Wright B, Edwards C, Gilbert R, Day R, Caddy S L
Cromwell Veterinary Group, Huntingdon, Cambridgeshire PE29 3DG, UK.
Magdalene College, Cambridge CB3 0AG, UK.
J Small Anim Pract. 2018 Jul;59(7):398-403. doi: 10.1111/jsap.12862. Epub 2018 Jun 7.
To investigate the benefit of supplementing amoxicillin-clavulanic acid therapy with metronidazole in dogs presenting to a primary care veterinary practice with severe haemorrhagic diarrhoea.
Prospective randomised blinded trial on dogs presenting with haemorrhagic diarrhoea of less than 3 days duration to a primary care veterinary hospital and also requiring intravenous fluid therapy. Cases were randomised to receive either metronidazole or saline, in addition to standard supportive therapy consisting of amoxicillin-clavulanic acid, intravenous fluid therapy, buprenorphine and omeprazole. Treatment efficacy was measured by duration of hospitalisation and daily scoring of disease severity.
Thirty-four cases successfully completed the trial. There was no significant difference in hospitalisation time between treatment groups (mean for dogs receiving metronidazole was 29.6 hours and for controls was 26.3 hours) nor in daily clinical scores.
This study strongly suggests that addition of metronidazole is not an essential addition to amoxicillin-clavulanic acid therapy for treatment of severe cases of haemorrhagic diarrhoea in dogs.
探讨在一家基层兽医诊所就诊的患有严重出血性腹泻的犬只中，联用甲硝唑辅助阿莫西林-克拉维酸治疗的益处。
对一家基层兽医医院收治的病程小于3天且需要静脉补液治疗的出血性腹泻犬只进行前瞻性随机双盲试验。病例被随机分为接受甲硝唑或生理盐水治疗，同时接受由阿莫西林-克拉维酸、静脉补液治疗、丁丙诺啡和奥美拉唑组成的标准支持治疗。通过住院时间和疾病严重程度的每日评分来衡量治疗效果。
34例病例成功完成试验。治疗组之间的住院时间（接受甲硝唑治疗的犬平均为29.6小时，对照组为26.3小时）和每日临床评分均无显著差异。
本研究强烈表明，对于治疗犬的严重出血性腹泻病例，联用甲硝唑并非阿莫西林-克拉维酸治疗的必要补充。
