Kirchner H, Keyssner M, Stünkel K G
Cell Immunol. 1986 Apr 1;98(2):560-3. doi: 10.1016/0008-8749(86)90316-3.
Suramin stimulated DNA synthesis in spleen cell cultures of all inbred strains of mice tested, including, for example, CBA, DBA/2, C57BL/6, and the lipopolysaccharide (LPS)-nonresponsive strain C3H/HeJ. The cells responding to the drugs were removed by passage through nylon wool columns, but they were not eliminated by in vivo treatment of the mice with anti-Thy 1.2 antibody. Spleen cells of homozygous nude mice (C57BL/6 or BALB/c background) were as reactive as those of their heterozygous littermates. Collectively the data show that suramin is a B-cell mitogen in the mouse.
苏拉明能刺激所测试的所有近交系小鼠脾细胞培养物中的DNA合成，这些小鼠品系包括，例如，CBA、DBA/2、C57BL/6，以及对脂多糖（LPS）无反应的品系C3H/HeJ。对该药物有反应的细胞通过尼龙毛柱传代后被去除，但用抗Thy 1.2抗体对小鼠进行体内处理并不能消除这些细胞。纯合裸鼠（C57BL/6或BALB/c背景）的脾细胞与其杂合子同窝小鼠的脾细胞反应性相同。总体而言，数据表明苏拉明是小鼠中的一种B细胞促有丝分裂原。
