Kim Hyung-Sik, Jung Junyang, Dong Sung Hwa, Kim Sang Hoon, Jung Su Young, Yeo Seung Geun
Department of Otolaryngology-Head and Neck Surgery, Graduate School, Kyung Hee University, Seoul, Korea.
Department of Anatomy and Neurobiology, School of Medicine, Kyung Hee University, Seoul, Korea.
Clin Exp Otorhinolaryngol. 2019 Aug;12(3):261-266. doi: 10.21053/ceo.2018.01018. Epub 2018 Dec 15.
Factors predictive of the severity of and recovery from Bell's palsy remain unclear. This study evaluated the association between neutrophil to lymphocyte ratio (NLR) and the severity of and recovery from Bell's palsy.
This retrospective study included 51 patients who were hospitalized with Bell's palsy from 2015 to 2017. Degree of paralysis was assessed by House-Brackmann (H-B) grade. Patients with H-B grades 2-4 were classified as having mild to moderate palsy and patients with H-B grade 5 or 6 were classified as having severe palsy. Patients were evaluated for obesity, hypertension and diabetes mellitus, and blood tests were performed to determine NLR and platelet to lymphocyte ratio. Patients were treated with steroids and antiviral agents. H-B grade was assessed 1 week, 1 month, and 3 months after treatment.
NLR was significantly higher in patients with severe than with mild to moderate palsy (P=0.048). Recovery time was significantly longer in patients with high NLR than low NLR (P=0.045).
Higher NLR in patients with Bell's palsy was associated with longer recovery time. NLR may be prognostic of recovery time in patients with Bell's palsy.
贝尔面瘫严重程度及恢复情况的预测因素仍不明确。本研究评估了中性粒细胞与淋巴细胞比值（NLR）与贝尔面瘫严重程度及恢复情况之间的关联。
这项回顾性研究纳入了2015年至2017年因贝尔面瘫住院的51例患者。采用House-Brackmann（H-B）分级评估瘫痪程度。H-B分级为2-4级的患者被归类为轻度至中度面瘫，H-B分级为5级或6级的患者被归类为重度面瘫。对患者进行肥胖、高血压和糖尿病评估，并进行血液检测以确定NLR和血小板与淋巴细胞比值。患者接受类固醇和抗病毒药物治疗。治疗后1周、1个月和3个月评估H-B分级。
重度面瘫患者的NLR显著高于轻度至中度面瘫患者（P = 0.048）。NLR高的患者恢复时间显著长于NLR低的患者（P = 0.045）。
贝尔面瘫患者较高的NLR与较长的恢复时间相关。NLR可能是贝尔面瘫患者恢复时间的预后指标。
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