由链球菌促有丝分裂毒素刺激的人T淋巴细胞产生大量获得性免疫缺陷综合征病毒（淋巴结病相关病毒）。
High production of the acquired immunodeficiency syndrome virus (lymphadenopathy-associated virus) by human T lymphocytes stimulated by streptococcal mitogenic toxins.
作者信息
Alouf J E, Geoffroy C, Klatzmann D, Gluckman J C, Gruest J, Montagnier L
出版信息
J Clin Microbiol. 1986 Oct;24(4):639-41. doi: 10.1128/jcm.24.4.639-641.1986.
Abstract
Purified streptococcal mitogens (SMs) including erythrogenic exotoxin were compared with phytohemagglutinin (PHA) for their ability to sustain lymphadenopathy-associated virus (LAV) replication after the stimulation of normal human peripheral blood mononuclear cells and purified CD4+ and CD8+ T cells infected with LAV. Both SM and PHA supported LAV production in peripheral blood mononuclear and CD4+ cells but not in CD8+ cells. LAV production assessed by the assay of reverse transcriptase in cell supernatants appeared earlier after stimulation with SM and was 6- to 10-fold greater than after stimulation by PHA.
摘要
将包括致热外毒素在内的纯化链球菌有丝分裂原（SMs）与植物血凝素（PHA）相比较，观察它们在刺激感染淋巴结病相关病毒（LAV）的正常人外周血单个核细胞以及纯化的CD4+和CD8+ T细胞后，维持LAV复制的能力。SM和PHA均能支持外周血单个核细胞和CD4+细胞产生LAV，但不能支持CD8+细胞产生LAV。通过检测细胞上清液中的逆转录酶来评估LAV产生情况，结果显示，用SM刺激后LAV产生得更早，且比用PHA刺激后的产量高6至10倍。
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