用MPTP进行慢性治疗后，给予GM1神经节苷脂可恢复纹状体中的多巴胺含量。
Administration of GM1 ganglioside restores the dopamine content in striatum after chronic treatment with MPTP.
作者信息
Hadjiconstantinou M, Rossetti Z L, Paxton R C, Neff N H
出版信息
Neuropharmacology. 1986 Sep;25(9):1075-7. doi: 10.1016/0028-3908(86)90206-6.
PMID:3490632
Abstract
The dopamine (DA) content of the mouse striatum thirty days after treatment with MPTP is significantly reduced. GM1 ganglioside administration during the thirty day period results in a partial restoration of the striatal DA content.
摘要
用MPTP治疗30天后，小鼠纹状体中的多巴胺（DA）含量显著降低。在这30天期间给予GM1神经节苷脂可使纹状体DA含量部分恢复。
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