Molecular Pharmacology Program, Sloan Kettering Institute and Gastrointestinal Oncology Service, Memorial Hospital, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Nat Rev Gastroenterol Hepatol. 2022 Feb;19(2):93-94. doi: 10.1038/s41575-021-00569-4.
Important colorectal cancer (CRC) studies in 2021, including a new standard of care for first-line treatment of MSI-H–dMMR metastatic CRC, single-cell and spatial analysis of primary tumours and investigations of diet in preclinical models of cancer initiation, have provided novel insights into the CRC immune microenvironment.
2021 年重要的结直肠癌（CRC）研究，包括微卫星高度不稳定（MSI-H）-错配修复缺陷（dMMR）转移性 CRC 一线治疗的新标准，原发性肿瘤的单细胞和空间分析，以及癌症起始的临床前模型中饮食的研究，为 CRC 免疫微环境提供了新的见解。
