Bhinde Sonam S, Ravi Arun Kumar, Patgiri Biswajyoti J, Harisha C R, Shukla Vinay J
PhD Scholar, Department of Rasa Shastra and Bhaishajya Kalpana, ITRA, Jamnagar, Gujarat, India.
Head, Department of Rasa Shastra and Bhaishajya Kalpana, ITRA, Jamnagar, Gujarat, India.
Ayu. 2020 Apr-Jun;41(2):117-122. doi: 10.4103/ayu.AYU_299_20. Epub 2021 Oct 23.
(purification) is the process by which one can remove the impurity or toxicity of the raw drug and make the drug suitable for therapeutic purpose. ( Linn.) is well known drug in Ayurveda and root of this plant is being used for therapeutic purpose and requires purification before used as a medicine.
There is no data available for pharmacognostical and analytical profile of processed , hence it was planned to develop SOP of processed for its identity, purity and strength through pharmacognostical and analytical profile.
roots were procured from Pharmacy, Gujarat Ayurved University, Jamnagar. Purification was done in five batches with Churnodaka (lime water). Organoleptic characters, microscopic features, pH, loss on drying, ash value, water soluble extracts, methanol soluble extracts and plumbagin quantification through high-performance thin layer chromatography (HPTLC) were carried out, before and after the purification.
Average 98.07% yield of was obtained after purification. Differences were found in the processed samples of in organoleptic features, pharmacognostical characters and physicochemical parameters, which show the impact of purification procedure on . In HPTLC profile, plumbagin content was 0.29% in unpurified powder, where in it was noted 0.98% after purification.
Increase in plumbagin content through pharmaceutical process of purification with lime water indicates that, this operating procedure is simple, convenient and can be considered as standard procedure. The organoleptic features, pharmacognostical characters, values of physicochemical parameters and quantity of plumbagin of purified powder may be utilized for quality assurance in future studies.
（纯化）是一种能够去除生药杂质或毒性，使药物适合治疗用途的过程。（林奈）是阿育吠陀中一种著名的药物，这种植物的根被用于治疗目的，在用作药物之前需要进行纯化。
目前尚无关于加工后（药物名称未明确给出，推测为某种植物药物）的生药学和分析概况的数据，因此计划通过生药学和分析概况制定加工后（药物名称）的标准操作规程，以确定其身份、纯度和强度。
根从贾姆讷格尔古吉拉特阿育吠陀大学药学院采购。用搅乳水（石灰水）分五批进行纯化。在纯化前后，对其感官特征、微观特征、pH值、干燥失重、灰分值、水溶性提取物、甲醇溶性提取物以及通过高效薄层色谱法（HPTLC）进行的白花丹素定量分析。
纯化后平均获得98.07%的（药物名称）产量。在（药物名称）的加工样品中，感官特征、生药学特征和理化参数存在差异，这表明纯化过程对（药物名称）有影响。在HPTLC图谱中，未纯化的（药物名称）粉末中白花丹素含量为0.29%，纯化后为0.98%。
通过用石灰水对（药物名称）进行纯化的制药过程提高了白花丹素含量，表明该操作程序简单、方便，可被视为标准程序。纯化后的（药物名称）粉末的感官特征、生药学特征、理化参数值和白花丹素含量可用于未来研究中的质量保证。
