Gursoy Asli Yarci, Caglar Gamze Sinem, Kiseli Mine, Pabuccu Emre, Candar Tuba, Demirtas Selda
Ufuk University Faculty of Medicine, Obstetrics and Gynecology Department , Ankara , Turkey.
Ufuk University Faculty of Medicine, Biochemistry Department , Ankara , Turkey.
Interv Med Appl Sci. 2015 Dec;7(4):143-6. doi: 10.1556/1646.7.2015.4.2.
C-reactive protein (CRP) is a well-known marker of inflammation and infection in clinical practice. This study is designed to evaluate CRP levels in different phases of menstrual cycle, which might end up with misleading conclusions especially when used for cardiovascular risk assessment.
Twenty-seven women were eligible for the cross-sectional study. Venous blood samples from each participant were collected twice during the menstrual cycle. The first sampling was held at 2nd to 5th days of the menstrual cycle for FSH, estradiol, CRP, and sedimentation, and the second was done at 21st to 24th days of the menstrual cycle for measurement of progesterone, CRP, and sedimentation values.
CRP values were significantly higher in the early follicular phase compared to luteal phase (1.8 mg/L [0.3-7.67] vs. 0.7 mg/L [0.1-8.3], p < 0.001, respectively). In both phases of the menstrual cycle, sedimentation rate was similar (12.1 ± 6.7 vs. 12.3 ± 7.7; p = 0.717, respectively).
CRP levels in early follicular phase of the menstrual cycle (menstruation) are significantly higher than CRP levels in luteal phase of the same cycle. In reproductive age women, detection of CRP for cardiovascular risk assessment during menstruation might not be appropriate.
C反应蛋白（CRP）是临床实践中炎症和感染的知名标志物。本研究旨在评估月经周期不同阶段的CRP水平，特别是在用于心血管风险评估时，这可能会得出误导性结论。
27名女性符合横断面研究的条件。在月经周期中，从每位参与者采集两次静脉血样。第一次采样在月经周期的第2至5天进行，检测卵泡刺激素（FSH）、雌二醇、CRP和血沉；第二次采样在月经周期的第21至24天进行，测量孕酮、CRP和血沉值。
与黄体期相比，卵泡早期的CRP值显著更高（分别为1.8mg/L[0.3 - 7.67]和0.7mg/L[0.1 - 8.3]，p < 0.001）。在月经周期的两个阶段，血沉率相似（分别为12.1±6.7和12.3±7.7；p = 0.717）。
月经周期卵泡早期（月经期）的CRP水平显著高于同一周期黄体期的CRP水平。对于育龄期女性，在月经期间检测CRP用于心血管风险评估可能不合适。
