National Drug and Alcohol Research Centre, University of New South Wales, Randwick, New South Wales, Australia.
School of Psychological Sciences, University of Tasmania, Sandy Bay, Tasmania, Australia.
Alcohol Clin Exp Res. 2021 Dec;45(12):2518-2527. doi: 10.1111/acer.14726. Epub 2021 Dec 18.
Different forms of alcohol-related harm (e.g., hangovers, fighting) may confer differential risk of clinically relevant alcohol problems. We examine: (i) patterns of transition in experiencing alcohol-related harms across adolescence; (ii) whether factors in early adolescence predict transition patterns; and (iii) whether transition patterns predict later alcohol use disorder (AUD) symptoms.
We used a longitudinal Australian cohort (n = 1828) to model latent class transition patterns of alcohol-related harms across three timepoints (M = 13.9, 16.8, 18.8 years). Regression models assessed whether child, peer, and parent factors in early adolescence (M = 12.9) predicted harms transition patterns and whether these patterns predicted AUD symptoms in early adulthood (M = 19.8).
Five transition patterns characterized most of the cohort (n ≈ 1609, 88.0%): (i) minimal harms (n ≈ 381, 20.8%); (ii) late physiological harms (n ≈ 702, 38.4%); (iii) early physiological harms (n ≈ 226, 12.4%); (iv) late all harms (n ≈ 131, 7.2%); and (v) gradual all harms (n ≈ 169, 9.2%). With late physiological harms as the reference, females had increased risk of experiencing early physiological harms (relative risk [RR]: 2.15; 99.5% CI: 1.19, 3.90). Late all harms (RR: 1.71; CI: 1.19, 2.47) and gradual all harms (RR: 1.84; CI: 1.37, 2.47) were each associated with increased odds of meeting criteria for AUD, even when patterns of alcohol consumption are considered.
Adolescents display heterogeneous transition patterns across physiological and psychosocial alcohol-related harms. Females are at greater risk of experiencing early physiological harms. Experience of both physiological and psychosocial harms in late adolescence is an important and potentially modifiable precursor to clinically relevant alcohol problems in early adulthood.
不同形式的酒精相关伤害（例如宿醉、打架）可能会带来不同的临床相关酒精问题风险。我们研究了：（i）青少年时期经历酒精相关伤害的转变模式；（ii）青少年早期的因素是否预测转变模式；（iii）转变模式是否预测后期的酒精使用障碍（AUD）症状。
我们使用一项澳大利亚纵向队列研究（n=1828），对三个时间点（M=13.9、16.8、18.8 岁）的酒精相关伤害的潜在类别转变模式进行建模。回归模型评估了青少年早期（M=12.9）的儿童、同伴和父母因素是否预测伤害转变模式，以及这些模式是否预测成年早期的 AUD 症状。
五种转变模式描述了大多数队列（n≈1609，88.0%）：（i）最小伤害（n≈381，20.8%）；（ii）晚期生理伤害（n≈702，38.4%）；（iii）早期生理伤害（n≈226，12.4%）；（iv）晚期所有伤害（n≈131，7.2%）；和（v）逐渐所有伤害（n≈169，9.2%）。以晚期生理伤害为参照，女性发生早期生理伤害的风险增加（相对风险[RR]：2.15；99.5%CI：1.19，3.90）。晚期所有伤害（RR：1.71；CI：1.19，2.47）和逐渐所有伤害（RR：1.84；CI：1.37，2.47）与 AUD 标准的可能性增加相关，即使考虑了饮酒模式。
青少年在生理和心理社会酒精相关伤害方面表现出不同的转变模式。女性发生早期生理伤害的风险更高。青春期晚期同时经历生理和心理社会伤害是成年早期出现临床相关酒精问题的一个重要且潜在可改变的前兆。
