Greenspan D, Greenspan J S, Hearst N G, Pan L Z, Conant M A, Abrams D I, Hollander H, Levy J A
J Infect Dis. 1987 Mar;155(3):475-81. doi: 10.1093/infdis/155.3.475.
We investigated the relation of oral hairy leukoplakia (HL) to human immunodeficiency virus (HIV) infection and to the presence or development of AIDS. All 155 patients with HL seen in our clinic were immunosuppressed homosexual men. Of 101 serum samples obtained from patients in this group who did not have AIDS, 100 showed antibodies to HIV. HIV was recovered from peripheral blood mononuclear cells of 22 of 28 patients tested. Most serum samples examined by immunoblot assay reacted with the viral envelope and gag gene precursors gp160 and p55. Of the 155 patients, 12 had AIDS at the time of diagnosis, and the syndrome developed in an additional 43 patients in one to 31 months. Survival analysis showed that the probability of AIDS developing in patients with HL was 48% by 16 months and 83% by 31 months. We conclude that oral HL is highly predictive of the development of AIDS.
我们研究了口腔毛状白斑（HL）与人类免疫缺陷病毒（HIV）感染以及艾滋病的存在或发展之间的关系。在我们诊所就诊的所有155例HL患者均为免疫抑制的同性恋男性。在该组未患艾滋病的患者中采集的101份血清样本中，100份显示出针对HIV的抗体。在接受检测的28例患者中的22例患者的外周血单核细胞中检测到了HIV。通过免疫印迹法检测的大多数血清样本与病毒包膜和gag基因前体gp160和p55发生反应。在这155例患者中，12例在诊断时患有艾滋病，另有43例患者在1至31个月内出现了该综合征。生存分析表明，HL患者发生艾滋病的概率在16个月时为48%，在31个月时为83%。我们得出结论，口腔HL对艾滋病的发展具有高度预测性。
