Li Yujing, Ye Fei, Zhang Shanxiang, Ni Wenjun, Wen Liewei, Qin Huan
MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, College of Biophotonics, South China Normal University, Guangzhou, China.
Zhuhai Precision Medical Center, Zhuhai People's Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai, China.
Front Bioeng Biotechnol. 2021 Dec 2;9:800744. doi: 10.3389/fbioe.2021.800744. eCollection 2021.
Multimodality imaging can reveal complementary anatomic and functional information as they exploit different contrast mechanisms, which has broad clinical applications and promises to improve the accuracy of tumor diagnosis. Accordingly, to attain the particular goal, it is critical to exploit multimodal contrast agents. In the present work, we develop novel cobalt core/carbon shell-based nanoparticles (Cobalt at carbon NPs) with both magnetization and light absorption properties for dual-modality magnetic resonance imaging (MRI) and photoacoustic imaging (PAI). The nanoparticle consists of ferromagnetic cobalt particles coated with carbon for biocompatibility and optical absorption. In addition, the prepared Cobalt at carbon NPs are characterized by transmission electron microscope (TEM), visible-near-infrared spectra, Raman spectrum, and X-ray powder diffraction for structural analysis. Experiments verify that Cobalt at carbon NPs have been successfully constructed and the designed Cobalt at carbon NPs can be detected by both MRI and PAI and . Importantly, intravenous injection of Cobalt at carbon NPs into glioblastoma-bearing mice led to accumulation and retention of Cobalt at carbon NPs in the tumors. Using such a multifunctional probe, MRI can screen rapidly to identify potential lesion locations, whereas PAI can provide high-resolution morphological structure and quantitative information of the tumor. The Cobalt at carbon NPs are likely to become a promising candidate for dual-modality MRI/PAI of the tumor.
多模态成像可以揭示互补的解剖学和功能信息，因为它们利用了不同的对比机制，这具有广泛的临床应用，并有望提高肿瘤诊断的准确性。因此，为了实现这一特定目标，开发多模态造影剂至关重要。在本工作中，我们开发了具有磁化和光吸收特性的新型钴核/碳壳基纳米颗粒（碳包覆钴纳米颗粒），用于双模态磁共振成像（MRI）和光声成像（PAI）。该纳米颗粒由涂有碳的铁磁钴颗粒组成，以实现生物相容性和光吸收。此外，通过透射电子显微镜（TEM）、可见-近红外光谱、拉曼光谱和X射线粉末衍射对制备的碳包覆钴纳米颗粒进行表征，以进行结构分析。实验证实碳包覆钴纳米颗粒已成功构建，并且设计的碳包覆钴纳米颗粒可以通过MRI和PAI检测到。重要的是，将碳包覆钴纳米颗粒静脉注射到荷胶质母细胞瘤小鼠体内会导致碳包覆钴纳米颗粒在肿瘤中积累和滞留。使用这种多功能探针，MRI可以快速筛查以识别潜在的病变位置，而PAI可以提供肿瘤的高分辨率形态结构和定量信息。碳包覆钴纳米颗粒很可能成为肿瘤双模态MRI/PAI的有前途的候选者。
