苯海拉明中毒致死。

Death caused by orphenadine poisoning.

作者信息

Sørensen H C, Munk-Jørgensen P

出版信息

Z Rechtsmed. 1986;97(2):133-9. doi: 10.1007/BF00204446.

DOI:10.1007/BF00204446

Abstract

The number of deaths as a consequence of orphenadine poisoning seems to increase, mostly among severely psychotic males. The lethal dose corresponds to the weekly average dose used in the treatment of neuroleptic extrapyramidal side effects. Based on the literature, the serious, rapidly incipient, cardiac, and neurologic symptoms of poisoning are emphasized. The handing out of orphenadine to suicidal persons must be restricted, and even small overdoses (1-2 g) ought to result in the immediate initiation of observation at an intensive care unit.

摘要

由于服用邻甲苯海明中毒导致的死亡人数似乎在增加，主要发生在患有严重精神疾病的男性中。致死剂量相当于用于治疗抗精神病药物锥体外系副作用的每周平均剂量。根据文献，强调了中毒严重、迅速出现的心脏和神经症状。必须限制向有自杀倾向的人发放邻甲苯海明，即使是小剂量的过量服用（1-2克）也应立即在重症监护病房进行观察。

相似文献

1

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本文引用的文献

1

[Orphenadrine poisoning].[邻甲苯海明中毒]

Ugeskr Laeger. 1981 Mar 16;143(12):753.

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Cardiotoxicity from orphenadrine intoxication in humans.人类因服用邻甲苯海明而导致的心脏毒性。

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General practitioners' selection of patients for treatment in community psychiatric services.全科医生为社区精神科服务挑选治疗患者。

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Treatment of orphenadrine overdose.奥芬那君过量的治疗。

N Engl J Med. 1977 Apr 28;296(17):1006. doi: 10.1056/NEJM197704282961721.

7

Forensic toxicology of some orphenadrine-related deaths.某些与邻甲苯海明相关死亡案例的法医毒理学

Forensic Sci. 1977 Jan-Feb;9(1):53-62. doi: 10.1016/0300-9432(77)90067-x.

8

[Orphenadrine poisoning (Disipal)].奥芬那君中毒（地西泮）

Ned Tijdschr Geneeskd. 1978 Jul 8;122(27):988-92.

9

Lethal orphenadrine intoxication: report of a case.致死性邻甲苯海明中毒：一例报告

Z Rechtsmed. 1979 Mar 8;82(4):349-53. doi: 10.1007/BF02092047.

10

Two cases of severe orphenadrine poisoning with atypical features.两例具有非典型特征的严重邻甲苯海明中毒病例。

Acta Pharmacol Toxicol (Copenh). 1977;41 Suppl 2:137-52.

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