Sørensen H C, Munk-Jørgensen P
Z Rechtsmed. 1986;97(2):133-9. doi: 10.1007/BF00204446.
The number of deaths as a consequence of orphenadine poisoning seems to increase, mostly among severely psychotic males. The lethal dose corresponds to the weekly average dose used in the treatment of neuroleptic extrapyramidal side effects. Based on the literature, the serious, rapidly incipient, cardiac, and neurologic symptoms of poisoning are emphasized. The handing out of orphenadine to suicidal persons must be restricted, and even small overdoses (1-2 g) ought to result in the immediate initiation of observation at an intensive care unit.
由于服用邻甲苯海明中毒导致的死亡人数似乎在增加，主要发生在患有严重精神疾病的男性中。致死剂量相当于用于治疗抗精神病药物锥体外系副作用的每周平均剂量。根据文献，强调了中毒严重、迅速出现的心脏和神经症状。必须限制向有自杀倾向的人发放邻甲苯海明，即使是小剂量的过量服用（1-2克）也应立即在重症监护病房进行观察。
