Malizia E, Sarcinelli L, Pascarella M, Ambrosini M, Smeriglio M, Russo A
Arch Toxicol Suppl. 1980;4:425-7. doi: 10.1007/978-3-642-67729-8_98.
Eight cases of Orphenadrine intoxication were treated in the Resuscitation Centre of Rome's University Medical School. All these cases arrived in coma, after taking an overdose of Orphenadrine in an attempt at suicide. The clinical signs and therapy are reported in detail; the cardiovascular side-effects, in particular those involving arrhythmias are dangerous and life threatening. From the clinical data it is believed that these changes in rhythm are mostly due to the autonomic nervous system (A.N.S.). In fact all the 8 patients survived, without treatment never having been treated with cardiokinetic or antiarrhythmic drugs, but a few were given Diazepam as well as respiratory assistance, cardiovascular assistance, and forced diuresis.
罗马大学医学院复苏中心对8例邻甲苯海明中毒病例进行了治疗。所有这些病例均因过量服用邻甲苯海明企图自杀而陷入昏迷。详细报告了临床症状和治疗方法；心血管副作用，尤其是涉及心律失常的副作用很危险，会危及生命。从临床数据来看，认为这些节律变化主要归因于自主神经系统（ANS）。事实上，所有8名患者均存活下来，未接受心动过速或抗心律失常药物治疗，但有少数患者接受了地西泮治疗，同时给予了呼吸支持、心血管支持和强制利尿。
